Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Advisor & Referee "Gollisch, Tim Prof. Dr."
Now showing items 1-20 of 28
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Role of PSD-95 in mouse binocular vision: A combined behavioural and 2-photon Ca2+ imaging study
(2025-10-22)Visual cortical circuits undergo a temporally restricted period of heightened plasticity early in neurodevelopment, termed the critical period (CP; Hubel and Wiesel, 1962, 1963). Crucial visual abilities, such as binocularity, ... -
Functional Characterization of Early Visual Neurons Using Machine Learning
(2025-10-02)Understanding how early visual neurons represent and process sensory input remains a central challenge in systems neuroscience. Key questions include how these neurons encode visual information, how their receptive fields ... -
Decoding Courtship Dynamics: The Role of Behavioral Rules, Feedback Cues and Internal State in Drosophila Interactions
(2025-08-29)The behavior of an organism is the result of sensorimotor transformations (behavioral rules) by which the brain integrates external sensory stimuli with its internal state to control a motor output and elicit a particular ... -
Multisensory integration of courtship song and taste in male Drosophila melanogaster social behavior
(2025-06-24)The integration of sensory information is essential for animals to effectively navigate and interact in their environment. For instance, the social life of male fruit flies is surrounded by various sensory modalities ... -
Functions and Origins of Nonlinear Processing in the Retina
(2024-11-29)Millions of people worldwide suffer from terminal blindness, but state-of-the-art vision restoration devices can only produce a sensation fundamentally different from natural seeing. We lack the sufficient understanding ... -
Development of an in-silico framework for the engineering and evaluation of future optogenetic cochlear implants
(2024-09-27)Hearing loss is a prevalent global challenge with profound cognitive, psychological, social, and economic implications. Traditional cochlear implants (CIs)—neuroprosthetic devices to partially restore hearing—stimulate the ... -
Developing tools for translational In-vivo cochlear optical stimulation
(2024-07-02)Utilizing optogenetic stimulation to target type I spiral ganglion neurons (SGNs) could promise an alternative to the currently employed electrical stimulation by current cochlear implants (CIs). Given light's spatial ... -
Investigation of a putative circuit in the mouse retina
(2024-06-27)Retinal ganglion cells of the vertebrate retina are tuned to detect specific features of the visual scene and effectively decompose it into different channels that are transmitted to and used by the brain to create the ... -
Ultrastructural study of synaptic vesicle dynamics in murine inner hair cell ribbon synapses under sustained stimulation
(2023-07-11)Transmission of auditory information relies in the correct functioning of inner hair cell (IHC) rib-bon synapses, which mediate synaptic vesicle release in an indefatigable manner. The name-giving synaptic ribbon and the ... -
Functional Decomposition of Retinal Ganglion Cell Receptive Fields
(2023-02-23)The retina has the fascinating ability to extract various visual features from our surroundings. This feature detection is enabled by nonlinear operations in the retinal circuitry. The nonlinear processing is in part ... -
How nonlinear processing shapes natural stimulus encoding in the retina
(2022-05-31)Understanding natural vision is one of the fundamental goals of sensory neuroscience. The only part of the visual system that may currently be amenable to such a complete understanding is the vertebrate retina, where there ... -
Strategies for dynamic vision in the Drosophila peripheral visual system
(2022-04-21)Changes in luminance over space and time drive visual behaviors across species. Thus, sensitivity to luminance changes or contrast is fundamental to visual perception. Visual perception has to work in many different ... -
Intracortical mechanisms compensating weakened thalamic input in the hyperexcitable somatosensory cortex of reeler mutant mice.
(2022-01-21)In the severely disorganized reeler primary somatosensory cortex, thalamocortical axons manage to target layer 4-fated neurons. Although the reeler somatosensory cortex maintains proper activation in response to sensory ... -
Neural representation of complex motion in the primate cortex
(2021-11-04)This dissertation is concerned with how information about the environment is represented by neural activity in the primate brain. More specifically, it contains several studies that explore the representation of visual ... -
Auditory associative learning and its neural correlates in the auditory midbrain
(2021-01-08)Interpreting the meaning of environmental stimuli to generate optimal behavioral responses is essential for survival. Simply sensing a sound, without accessing prior knowledge in the brain, will not benefit behavior. How ... -
Receptive field organization of motion computation in the fly: a study of cell types and their variability
(2020-12-02)It is believed that knowing all cell types making up a brain will lead to its understanding. Consequently, current efforts focus on classifying cell types according to their anatomical, genetic and physiological properties. ... -
Neuronal control of sleep in Caenorhabditis elegans
(2020-11-03)Sleep is crucial for all organisms with a nervous system. Amongst other functions, it is required for energy allocation, higher brain functions and the control of physiological processes. Sleep-active neurons have ... -
Towards Optical Cochlear Implants: Behavioral and Physiological Responses to Optogenetic Activation of the Auditory Nerve
(2019-11-15)Cochlear implants (CIs) constitute the interface between the sound-deprived brain of patients suffering from sensorineural hearing loss and the auditory scene surrounding them. By electrically stimulating the auditory nerve ... -
Thermosensory Transduction Mechanisms in Drosophila melanogaster
(2019-10-18)Ambient temperature has an profound effect in the physiology of all animals and accurate evaluation of both external and internal temperatures is therefore an essential factor for fitness and survival. To this end, animals ... -
Optogenetic stimulation of the cochlea
(2019-07-15)Optogenetic stimulation of the auditory nerve is a promising alternative to restore hearing. Since light can be focused on the target tissue, the optical cochlear implant (oCI) might support a major improvement in frequency ...