Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Advisor & Referee "Marquardt, Till Prof. Dr."
Now showing items 1-9 of 9
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Dlk1 Membrane-to-Nuclear Signalling During Motor Neuron Functional Diversification
(2017-11-20)Motor neurons of the spinal cord and hindbrain are responsible for translating neural commands into movements. For the execution of smooth movements, it is necessary that motor neuronal impulses are in turn translated into ... -
Modelling schizophrenia endophenotypes by overexpression of Neuregulin-1 isoforms in transgenic mice
(2017-09-13)Neuregulin 1 (NRG1) is the best characterized member of a family of epidermal growth factor (EGF)-like domain containing proteins that serve as ligands for tyrosine kinase receptors of the ErbB family. NRG1 and its main ... -
Molecular Control of Pyramidal Neuron Fate Determination in the Developing Neocortex
(2015-01-12)The pyramidal neurons of the neocortex, which form the neural substrate for our higher cognitive abilities, arise from a single layer of neuroepithelium lining the dorsal ventricles. It has been of immense interest to study ... -
The role of innervation during mouse embryonic myogenesis: what molecular genetics tells
(2013-06-19)The interdependency of motor neurons and the skeletal muscle is a classical example for instructive and trophic tissue interactions during development and adult life. It is well established that skeletal muscles undergo ... -
Exploring the neural basis of touch through selective and stable genetic tagging in the chick somatosensory system
(2013-01-03)The assembly of circuitries for somatosensory perception relies on a complex interplay of neuronal diversification, specification, phenotypic modulation and establishment of precise connectivity patterns during embryogenesis. ... -
The role of E3 ubiquitin ligase FBXO31-SCF in neuronal morphogenesis
(2013-01-03)Neuronal development is coordinated by the interplay of extrinsic cues and intrinsic factors. These extrinsic cues act through multiple intracellular signaling pathways to regulate the cytoskeleton machinery of the ... -
Neurodegeneration in toxin-mediated demyelinating animal models of Multiple Sclerosis
(2012-11-05)Myelin is produced by a specialized membrane of oligodendrocytes in the CNS. This multilayered structure enwraps axons, providing them with trophic support and facilitates the fast transmission of electric signals. To ... -
Identification and characterization of molecular mechanisms driving the functional specification of motor neurons The Delta like homolog 1 protein
(2012-03-02)Spinal Motor neurons are playing a decisive role in body posture and locomotion by controlling skeletal muscle contraction via their motor axon termini. During embryonic development motor ...