Blättern GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften nach "Dean, Camin Dr." Betreuer
Anzeige 1-6 von 6
-
A post-synaptic forgetting mechanism controlled by synaptotagmin 3
(2018-05-03)Activity-induced regulation of surface post-synaptic receptor number is a well-known mechanism underlying synaptic plasticity, but the molecular machinery mediating this process is poorly understood. In a screen of ... -
Activity-based automatic ROI generation (AARG) analysis of dendritic spine calcium transients reveals distance-dependent activity of voltage-gated calcium channels
(2018-03-20)Imaging synaptic activity in the form of calcium transients occurring in dendritic spines is advancing our understanding of nerve cell function beyond what can be achieved using electrophysiological methods alone. I have ... -
Molecular Mechanisms of Astrocyte Vesicle Fusion at Synaptic Interfaces
(2015-12-01)Astrocytes are key to neuronal trophic support, development, and synaptic signalling and plasticity. Astrocytes can detect synaptic events at tripartite synapses –a major site of bidirectional communication between neurones ... -
Nanoscale probing of single synapse function and BDNF Cell-to-Cell transfer
(2016-12-22)Brain-derived neurotrophic factor (BDNF) is one of the key modulator/mediator molecules for synaptic plasticity in the adult nervous system and also coordinates neural development, survival, differentiation and axon growth ... -
Phosphorylation of Synaptotagmin 4 captures transiting dense core vesicles at active synapses
(2017-03-03)Synaptic modulation requires fast recruitment of neuronal dense core vesicles (DCVs) containing various neuropeptides and neurotrophins at nerve terminals. DCVs undergo long-range trafficking in axons to deliver cargoes ... -
The Role of the Transient Receptor Potential Vanilloid 1 (TRPV1) Channel in Sharp Wave Ripples, Place Cells, and Spatial Memory
(2024-02-09)Previous research in our lab found impaired long-term potentiation (LTP) of CA3-CA1 synapses, a fundamental process for learning and memory, in transient receptor potential vanilloid 1 (TRPV1) knockout (KO) mice. The TRPV1 ...