Blättern GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften nach "Ebert, Antje PD Dr." Betreuer
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Characterizing intracellular lipid signaling in dilated cardiomyopathy using human iPSC-derived cardiac cells
(2023-04-18)Sarcomere protein misalignment is a primary consequence of inherited mutations causing dilated cardiomyopathy (DCM) and results in severe molecular patho-phenotypes in cardiomyocytes from patients. In this study, human ... -
Integrational modelling for molecular analysis in a CRISPR/Cas edited iPSC-cardiomyocyte model of Dilated Cardiomyopathy
(2023-07-05)Machine learning has shown promising results in the prediction and diagnosis of cardiac diseases. By analyzing large amounts of patient data, such as imaging, genomics, or molecular phenotyping data, machine learning ... -
Regulation of vesicular trafficking in presence of mutations in contractile proteins
(2022-06-20)The molecular and cellular mechanisms underlying disease phenotypes in dilated cardiomyopathy (DCM) are diverse and to date incompletely understood. Inherited mutations in genes encoding structural components of the sarcomere ...