Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Advisor "Fischer, André Prof. Dr."
Now showing items 1-16 of 16
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Altered Histone 4 K12 Acetylation is Associated with Age Dependent Memory Impairment in Mice
(2010-10-29)The remarkable capability of the nervous system of animals to adapt their behavioral responses to an ever-changing environmental conditions is thought to rely on the plasticity of neuronal ... -
Assessment of Epigenetic profile in Alzheimer's disease
(2012-11-30)Alzheimer's disease is caused by multivariate factors with a convergent insult to neuronal integrity leading to cognitive decline and neurodegeneration. To develop an efficient therapeutic strategy for treatment of AD calls ... -
Changes in gene expression linked to Alzheimer's disease and "healthy" cognitive aging
(2019-02-20)Alzheimer’s disease (AD) is a neurodegenerative disease and the most common form of dementia. The number of AD cases increases exponentially every year. Although AD has been investigated for a long time, the precise ... -
Coding and Non-Coding RNA in Age-Associated Memory Impairment and Alzheimer's Disease
(2014-06-03)The phenomenon of population aging, caused by increased life expectancy and declining birth rates, has resulted in a high, and continuously rising proportion of elderly people in the population. This means it is critical ... -
Decoding the Epigenome of Neuronal Networks in Health and Disease
(2019-05-27)Alzheimer’s disease (AD) is the most prevalent form of dementia that has vast emotional and economic implications in our society. There is no cure for this neurodegenerative disorder as the pathological changes occur years ... -
Epigenetic Biomarker and Therapeutic Intervention for Dementia
(2021-01-11)Dementia is the most significant health challenge in modern times, currently affecting over 50 million people worldwide. The number of people afflicted with this disorder is on the rise and expected to double by 2025. ... -
Epigenetic Modulation in Alzheimer's Disease: Function of Hippocampal microRNAs
(2015-12-04)MicroRNAs (miRNA) are small non-coding RNAs that play a critical role in the regulation of gene expression programs and thus key mediators of cellular homeostasis. There is increasing evidence that deregulation of miRNAs ... -
Epigenomic and transcriptomic analysis of developing, adult and aging brain: mechanisms of brain folding, neuronal function and finding novel therapy for dementia
(2021-10-13)Histone modifications and gene expression are tightly regulated processes in the brain that has been shown to play crucial role from the beginning of brain development, learning-memory formation and aging. While brain ... -
Epigenomic Imaging of Neuropsychiatric Diseases
(2013-12-13)Schizophrenia is a severe neuropsychiatric disorder with high phenotypic complexity and multifactorial inheritance. Cognitive dysfunctions have been identified as the core feature of the disease and they are resistant to ... -
Epitranscriptomic Regulation in Synaptic Plasticity, Aging and Neurodegeneration
(2023-02-03)The regulation of synaptic transmission and plasticity is essential for correct brain function, especially for learning and memory, while the weakening of synaptic transmission and loss of plasticity are hallmarks of the ... -
Establishing parameters for the characterization of rare neurometabolic and neurodegenerative diseases using mass-spectrometry based Metabolomics
(2021-10-18)Rare diseases are a class of disorders where every single disease has a low prevalence, but due to their incredible variety, they affect more than 100 million people worldwide. A significant number of these disorders lead ... -
Gene Expression Analysis in Models of Cognitive Diseases
(2023-04-18)Neuropsychiatric disorders and neurodegenerative diseases have been a subject of significant interest in the scientific community for several reasons. A considerable portion of the population experiences discomfort due to ... -
Role of Histone Methylation in Cognition and Effects of Different Durations of Environmental Enrichment on Learning and Memory
(2012-06-06)Part 1 Formation of stable long-term memories requires novel gene expression, and chromatin modifications have been shown to be involved in mediating the de novo gene expression which is necessary for memory formation. ... -
The influence of epigenetic alterations on synaptic function and memory
(2022-08-24)While memory formation is traditionally linked to changes in synaptic structure, the transcriptional processes enabling these changes are often understudied. Even though novel protein synthesis is the basis of long-term ... -
The role of Kat2a during memory formation and chromatin plasticity in the aging murine hippocampus
(2013-07-18)Evolution has equipped multicellular organisms with ever more sophisticated means of processing information about the environment they live in. The hippocampus has been shown to be one of the most important structures of ... -
The Synaptic RNAome - identification, interactions and intercellular transfer
(2021-03-19)Synaptic plasticity is how neurons adapt to new stimuli and necessitates changes in synaptic weight. For these changes to be durable, local translation in neurites, and at pre- and post-synapses is required. Current methods ...