Blättern GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften nach "Griesinger, Christian Prof. Dr." Betreuer
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A twist in NMR relaxation experiments: Application to the study of protein motions
(2019-09-27)Understanding biological processes requires knowledge about the structure as well as dynamics of the involved molecules. Proteins are complex structures, which experience time dependent changes due to atomic motions. The ... -
Accessing the kinetics of the supra-tauc range via relaxation dispersion NMR spectroscopy
(2013-10-30)Nuclear Magnetic Resonance spectroscopy (NMR) is capable of attaining dynamic information of motions over a broad range of time scales under physiological relevant conditions while maintaining atomic resolution. Of the ... -
From Paramagnetic Proteins to Field Alignment of Small Molecules
(2022-03-17)In this dissertation we show how to push the boundaries of structure elucidation using tensorial NMR parameters. Possible sources for these effects are paramagnetic centers or molecular alignment, and they contain valuable ... -
Functional dynamics of the anti-HIV lectin OAA and NMR methodology for the study of protein dynamics
(2016-01-26)Specific recognition between biomolecules is at the basis of all biological processes, and a mechanistic description of molecular recognition is crucial for a detailed understanding of these processes. Two limiting models ... -
Mechanistic insights into alpha-Synuclein neuronal toxicity: misfolding, serine phosphorylation and interactions with Rab GTPases
(2013-11-18)Alpha-Synuclein(aS), a protein abundant in presynaptic neurons, has been found as the major component of Lewy bodies, the neuronal inclusion identified as the hallmark of Parkinson’s disease (PD). aS adopts intrinsically ... -
On the molecular basis of α-synuclein aggregation on phospholipid membranes in the presence and absence of anle138b
(2020-07-22)A physiologic hallmark of synucleinopathies such as Parkinson’s Disease (PD) or Multiple System Atrophy (MSA) are deposits in patients’ brains, which consist of the α-synuclein. Growing evidence suggests, that oligomeric ... -
Paramagnetic Tagging of Oligonucleotides for Structure Determination using NMR-Spectroscopy
(2015-03-31)Structure determination is one of the most fundamental fields of research, as it provides insights in biological systems and their mechanisms. Therein, NMR spectroscopy is an essential tool for investigations under ... -
Phase Separation Studied by Nuclear Magnetic Resonance
(2024-01-04)Signal transduction by the ligated B cell receptor (BCR) depends on the pre-organization of its intracellular components, such as the effector proteins SLP65 and CIN85 within phase-separated condensates. These liquid-like ... -
Sensitivity Enhanced NMR
(2014-04-16)The topic of this thesis is the investigation of how sensitivity enhanced Nuclear Magnetic Resonance (NMR) spectra of biological systems could be obtained by dynamic nuclear polarization (DNP) under conditions close to ... -
Structural and Functional Investigations of Transmembrane Signaling Histidine Kinase Using NMR
(2022-11-04)Membrane proteins play a central role in biology as the gatekeepers of all cellular compartments. And transmembrane signaling through membrane bound kinases is a particularly important process for cellular adaptation to a ... -
Structural Studies on Transmembrane Signalling Mechanism of Histidine Kinase CitA
(2019-12-18)Perception of environmental changes and subsequent signal transduction are key aspects for the survival of an organism. In bacteria, two component systems (TCSs) consisting of a homodimeric receptor histidine kinase (HK) ... -
The Advantages Of Paramagnetic NMR
(2013-11-28)There are three distinct effects in nuclear magnetic resonance spectroscopy (NMR) that differ between paramagnetic and diamagnetic molecules in isotropic solution. These are residual dipolar coupling (RDC), pseudocontact ... -
Transmembrane Signalling: Structural and Functional Studies on Histidine Kinase CitA
(2015-12-03)Bacteria utilise two component systems (TCS) consisting of a homodimeric receptor histidine kinase (HK) and a response regulator (RR) as a prevalent mechanism of stimulus perception and signal transduction. TCSs are key ...