Blättern GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften nach "Janshoff, Andreas Prof. Dr." Betreuer
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Active and Passive Microrheology of F-Actin Membrane Composites
(2018-07-19)The complex mechanical properties of a living cell are not only a function of its structural components but also of the organizational super-structure and the dynamic interconnection of filaments, proteins and the plasma ... -
Cellular locomotion and adhesion in the context of different substrate properties
(2017-01-16)This work comprises three different projects dealing with the interplay of cellular locomotion and adhesion to establish a better understanding of the response of cells to their environment. In the first part of this thesis ... -
Collective Mechanical Behavior of Epithelial Cells - The Impact of Micro-Wounding
(2019-06-24)For epithelia, which are lining organs or blood vessels, the mechanical integrity of a whole cell sheet is indispensable. The question arises, how neighboring cells mechanically work together to build a functioning cell ... -
Colloidal Probe Force Spectroscopy
(2021-10-26)This thesis demonstrates how colloidal probe force spectroscopy, in connection with reconstituted biological model systems and theoretical models, allows us to investigate and understand the behavior of a wide variety ... -
Cortical Tension of Cells: From Apical Membrane Patches to Patterned Cells
(2018-12-05)During their lifetime, cells and tissues have to deal with a variety of mechanical challenges. Shear forces exist inside of vessels, bones have to carry the weight of organisms and connective tissues are generally deformed ... -
Dynamics and mechanics of adherent cells in the context of environmental cues
(2015-03-25)Cellular behavior is influenced by many biochemical but also physical factors in the direct cellular environment. Thereby, cells not only react to external cues, the interaction between cells and their environment is also ... -
Effects of arginine derivatives and oligopeptides on the physical properties of model membranes
(2021-02-16)Cell-penetrating peptides (CPPs) are often rich in arginine. They are able to cross cell membranes and carry other molecules into cells without being cytotoxic. The mechanisms by which they accomplish this are still ... -
Investigation of membrane fusion as a function of lateral membrane tension
(2017-09-21)Membrane fusion in native systems occurs on very short time scales and it has been proposed that lateral membrane tension of the presynaptic membrane is substantially increased to facilitate fusion. Proteins of the SNARE ... -
Mechanics and Motility of Epithelial Cells: From Single Cell Behavior to Collective Migration
(2023-01-13)Mechanical behavior of cells plays a crucial role in a plethora of biological processes. Despite its importance, this aspect of life science has only more recently gained increasing interest. Yet, without mechanical force ... -
Membrane tension homeostasis of mammalian cells
(2017-04-12)Although a cell is the smallest unit that is viable on its own, its construction and processes are of great complexity. Many functions, which keep a cell alive, are only poorly understood up to now. Plasma membrane tension ... -
Structure and Mechanics of Neuronal Model Systems
(2019-11-15)Neurons of advanced animals need fast and efficient mechanisms to enable the functionality of a complex nervous system. In the life cycle of synaptic vesicles this is reflected in the endocytosis which generates new vesicles, ...