Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Advisor "Johnsen, Steven Prof. Dr."
Now showing items 1-6 of 6
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Epigenetic regulation of osteoblast differentiation
(2017-06-07)Proper temporal epigenetic regulation of gene expression is essential for cell fate determination and tissue development. However, epigenetic mechanisms involved in control of bone-specific transcriptional programs remain ... -
Regulation of H2B Monoubiquitination Pathway in Breast cancer
(2015-01-23)H2B monoubiquitination (H2Bub1) regulation via CDK9-WAC-RNF20/40 axis has been well illustrated. It is interesting to determine the upstream regulators which dictate the process of monoubiquitination of H2B. On further ... -
Role of BRD4 and histone acetylation in estrogen receptor-positive breast cancers
(2015-09-10)The estrogen receptor-α (ERα) acts as a nuclear transcription factor to promote estrogen-induced transcription and plays a central role in the progression of ER-positive tumors. ERα binds to the consensus DNA elements ... -
The role and regulation of histone H2B monoubiquitination during tumorigenesis
(2014-05-23)Posttranslational histone modifications are recognized as important regulators of gene expression. One of them, the monoubiquitination of lysine 120 of histone H2B (H2Bub1), has diverse functions and is involved in gene ... -
The role of H2B monoubiquitination in cellular differentiation
(2013-06-24)Histones, subjected to post-translational modifications, are important regulators of the cellular processes. One of these modifications is monoubiquitination of histone H2B (H2Bub1). H2Bub1 is associated with the actively ... -
The role of the FACT complex in differentiation of multipotent stem cells
(2017-04-27)Cellular differentiation is accompanied by dramatic changes in chromatin structure which are associated with the activation of lineage-specific transcriptional programs. Facilitates Chromatin Transcription (FACT) is a ...