Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Advisor "Johnsen, Steven Prof. Dr."
Now showing items 1-15 of 15
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Epigenetic regulation of osteoblast differentiation
(2017-06-07)Proper temporal epigenetic regulation of gene expression is essential for cell fate determination and tissue development. However, epigenetic mechanisms involved in control of bone-specific transcriptional programs remain ... -
Epigenetic Regulation of Tumor Cell Phenotype
(2017-04-03)The Transforming Growth Factor-β (TGFβ)/SMAD signaling pathway can function as either a tumor suppressor or metastasis promoter during tumor progression. In normal epithelial cells and early stages of epithelial ... -
Gemcitabine Resistance Elicits a Calcium Dependent Epigenetic Reprogramming in Pancreatic Cancer
(2021-03-08)Pancreatic cancer is a dismal malignancy with a 5-year survival rate of 7-9%, one of the worst among all cancer types. Patients with pancreatic ductal adenocarcinoma (PDAC) usually present an advanced stage of the disease ... -
Regulation of H2B Monoubiquitination Pathway in Breast cancer
(2015-01-23)H2B monoubiquitination (H2Bub1) regulation via CDK9-WAC-RNF20/40 axis has been well illustrated. It is interesting to determine the upstream regulators which dictate the process of monoubiquitination of H2B. On further ... -
Role of BRD4 and histone acetylation in estrogen receptor-positive breast cancers
(2015-09-10)The estrogen receptor-α (ERα) acts as a nuclear transcription factor to promote estrogen-induced transcription and plays a central role in the progression of ER-positive tumors. ERα binds to the consensus DNA elements ... -
Role of Distal Regulatory Elements in Cancer Progression and Therapy
(2019-01-11)Enhancer elements comprise of regions of DNA that are distal to gene promoters with a characteristic capacity to affect and regulate gene transcription. Enhancers are enriched in a highly context-specific manner allowing ... -
Role of Histone Metabolism and Chromatin Structure in DNA Repair
(2014-06-11)During the cell cycle progression, synthesis of new histones is important to pack newly synthesized DNA and to maintain proper chromatin structure. Unlike normal mRNAs, mRNAs from replication-dependent histone genes that ... -
The Cellular Function of USP22 and its Role in Tissue Maintenance and Tumor Formation
(2018-02-12)Colorectal cancer (CRC) is the most frequent malignancy of the gastrointestinal tract and therefore reflects a global health issue. Despite improved detection and treatment options the high mortality and morbidity rates ... -
The role and regulation of histone H2B monoubiquitination during tumorigenesis
(2014-05-23)Posttranslational histone modifications are recognized as important regulators of gene expression. One of them, the monoubiquitination of lysine 120 of histone H2B (H2Bub1), has diverse functions and is involved in gene ... -
The Role of ARID1A in Oncogenic Transcriptional (de)Regulation in Colorectal Cancer
(2019-07-23)The deregulation of epigenetic modulation has been well established as a common occurrence in cancer. However, the extent of its involvement in the development and progression of cancer was underscored by genome- and ... -
The Role of BRDT in Esophageal Squamous Cell Carcinoma
(2021-01-08)Esophageal squamous cell carcinoma (ESCC), the predominant subtype of esophageal cancer, remains a deadly malignancy due to the lack of effective therapies. Precision oncology, utilizing various techniques to identify ... -
The Role of CHD1 during Mesenchymal Stem Cell Differentiation
(2017-01-23)Nucleosome remodeling, histone modifications and exchange of histone variants are interconnected mechanisms involved in regulation of gene transcription. Nucleosomes can act as strong barriers and are remodeled during ... -
The role of H2B monoubiquitination in cellular differentiation
(2013-06-24)Histones, subjected to post-translational modifications, are important regulators of the cellular processes. One of these modifications is monoubiquitination of histone H2B (H2Bub1). H2Bub1 is associated with the actively ... -
The Role of RNF40 mediated H2B monoubiquitination in transcription
(2017-02-13)Active gene transcription is tightly correlated with the occupancy of histone H2B monoubiquitination (H2Bub1) in the transcribed region. Therefore, it is has been commonly assumed that H2Bub1 is an exclusively positively ... -
The role of the FACT complex in differentiation of multipotent stem cells
(2017-04-27)Cellular differentiation is accompanied by dramatic changes in chromatin structure which are associated with the activation of lineage-specific transcriptional programs. Facilitates Chromatin Transcription (FACT) is a ...