Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Advisor "Krebber, Heike Prof. Dr."
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Characterization of mRNA export and nuclear quality control under heat stress in the yeast Saccharomyces cerevisiae
(2017-05-17)Elevated temperatures and other changes of the environment a cell lives in, can have tremendous impact on cellular processes and integrity. To counteract these threats, cells have established various mechanisms to avoid ... -
Characterization of Npl3-mediated RNA quality control in Saccharomyces cerevisiae
(2018-12-19)During all steps of nuclear RNA maturation, aberrant RNAs can be generated. However, nuclear quality control mechanisms ensure that immature or aberrant RNAs are retained in the nucleus and subsequently degraded to prevent ... -
Characterization of the stepwise maturation of the telomerase RNA TLC1 and assembly of the telomerase in Saccharomyces cerevisiae
(2021-11-04)Telomere length homeostasis is a prerequisite for cell viability. It is challenged through successive shortening, which is due to the “end-replication-problem”. This limits the cellular life span in multicellular organisms ... -
Gbp2 and Hrb1 continue their mRNA quality control in the cytoplasm and take part in Nonsense Mediated Decay
(2019-09-02)The eukaryotic mRNA life cycle is orchestrated by many pathways. Every aspect of this life cycle is associated with quality control factors. This tight coupling of mRNA transcription, processing, export and translation ... -
Maturation and nucleo-cytoplasmic shuttling of snRNAs in Saccharomyces cerevisiae
(2019-01-24)While nucleo-cytoplasmic shuttling of snRNAs is a well known process in higher eukaryotes, it is still unknown whether snRNAs shuttle in Saccharomyces cerevisiae. Furthermore, it is unclear why snRNA shuttling evolved in ... -
Nuclear mRNA quality control factors Gbp2 and Hrb1 take part in cytoplasmic mRNA surveillance through nonsense-mediated decay
(2022-01-27)Yeast SR-like proteins Gbp2 and Hrb1 shuttle between the nucleus and the cytoplasm, and serve as quality control factors for pre-mRNA splicing. They are loaded onto the RNA co-transcriptionally, and upon correct splicing, ...