Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Advisor "Stülke, Jörg Prof. Dr."
Now showing items 1-17 of 17
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Characterization of abundant unknown proteins that participate in the control of tRNA maturation and fatty acid acquisition in Bacillus subtilis
(2024-07-23)Despite tremendous advances in sequencing and other state-of-the-art technologies, unknown proteins are present in virtually all living organisms. Even though Bacillus subtilis is one of the most extensively annotated model ... -
Function and homeostasis of non-proteinogenic amino acids in Bacillus subtilis
(2024-07-23)The gram-positive soil bacterium Bacillus subtilis lives in a constantly changing environment, requiring rapid adaptation to survive and thrive. This forces the bacteria to adapt to nutrient availability or stressful ... -
Amino acid metabolism in Bacillus subtilis
(2024-03-05)Amino acid metabolism is a a central field of research aiming to understand the complex reactions that take place in a cell. Amino acids are the main building blocks for proteins, and they serve as carbon or nitrogen source ... -
Validation of novel protein-protein interactions in Bacillus subtilis
(2023-01-12)Protein-protein interactions are the basis for many biological processes in the cell. Understanding these interactions is crucial for the general analysis of how the cell functions and the potential identification of ... -
From annotation to bacterial data models
(2022-06-24)Science and technological advancements walk side-by-side and with the recent emergence of novel high throughput techniques, the necessity to have specialized data structures to host and represent the complex and high variety ... -
Protein Interactions in minimal cells
(2022-05-18)Minimal cells are used to model and understand life’s complex processes. The most essential processes of life are thought to include cell replication, energy metabolism and genome maintenance. However, construction of a ... -
Signal transduction by the essential nucleotide second messenger cyclic di-AMP in Bacillus subtilis
(2021-01-15)Bacillus subtilis, as a soil inhabitant, has to adapt to rapidly changing osmotic conditions. The response to these osmotic changes represents one of the most critical issues in the lifecyle of bacteria, and the tight ... -
A possible functional link between RNA degradation and transcription in Bacillus subtilis
(2020-09-24)Cellular levels of RNA depend on the rate of its synthesis and degradation. While synthesis is performed by RNA polymerase conserved in all domains of life, the enzymes responsible for RNA degradation are more unique ... -
A protein in search of a function: The c-di-AMP-binding protein DarA of Bacillus subtilis
(2019-07-26)Adaptation to changing environmental conditions is crucial for any organism to thrive in nature. Bacteria like the Gram-positive model organism Bacillus subtilis have evolved so-called second messengers to facilitate ... -
Identification of essential and virulence genes in Mycoplasma pneumoniae
(2019-04-16)The bacterial group of Firmicutes includes many pathogenic bacteria, as Mycoplasma pneumoniae. The Gram-positive, but cel wall-less bacterium is characterized by a minimal genome with only 694 genes. Elucidating the function ... -
MiniBacillus - the construction of a minimal organism
(2019-04-04)The MiniBacillus project is a minimal genome project. It attempts to reduce the genome of the model organism Bacillus subtilis in a top-down approach by deleting not necessary parts of the genome step by step. In this work, ... -
Insights into the biofilm formation of Bacillus subtilis
(2018-10-01)Bacillus subtilis forms highly structured biofilms to protect itself against harmful environments, and to have an advantage in the competition with other species. The cells of B. subtilis that secrete the biofilm matrix, ... -
SubtiWiki 3.0: A relational database for the functional genome annotation of the model organism Bacillus subtilis
(2018-02-12)Biological databases emerged in the 1970s along with the rapid development of information science. Since then, they have greatly helped the research community in data management and information sharing, especially the model ... -
Control of biofilm formation in Bacillus subtilis
(2015-05-12)Biofilms can be considered as one main lifestyle of many bacteria in their natural environment. A bacterial biofilm is a cell community that is surrounded by a self-produced extracellular matrix. This matrix usually consists ... -
Bildung und Homöostase von c-di-AMP in Bacillus subtilis
(2014-07-14)Signal transduction describes the ability of cells to sense environmental stimuli and transfer this information in order to react appropriately to these stimuli. In this process, signaling nucleotides are often important. ... -
Regulatory interactions of enzymes of the citric acid cycle in Bacillus subtilis
(2013-01-25)In most organisms the tricarboxylic acid (TCA) cycle is a fundamental hub in metabolism. The TCA cycle is the origin and the endpoint of a broad spectrum of intermediates and provides the cell with energy and cellular ... -
Systems biology in Bacillus subtilis
(2010-11-16)Systems biology studies the way in which interaction of different types of molecules results in complex behaviour at the cellular, organism, and higher levels. It approaches these questions ...