Blättern GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften nach "Wienands, Jürgen Prof. Dr." Betreuer
Anzeige 1-7 von 7
-
Identification of therapeutic targets in the Burkitt’s lymphoma specific B cell antigen receptor signaling network
(2018-11-12)Burkitt’s lymphoma (BL) is an aggressive B cell neoplasm that is characterized by a chromosomal translocation, which brings the proto-oncogene c-MYC under the control of Immunoglobulin (Ig) enhancer elements leading to ... -
Molecular mechanism of B cell antigen receptor-induced SHIP activation
(2012-03-05)Regulation of B cell activation is highly important to keep the balance between immunity and self-tolerance. The SH2 domain-containing 5 inositol phosphatase (SHIP) is an inhibitor of B ... -
Multimolecular adaptor protein complexes in B cell receptor signaling
(2015-07-03)The activation of B cells is the crucial step of the humoral immune response. This process is controlled by the B cell receptor (BCR) signaling pathway which is initiated by antigen recognition. An elaborated and detailed ... -
Structural and functional elucidation of the primary transducer module of the B cell antigen receptor
(2015-07-27)Interaction of an antigen with the B cell antigen receptor (BCR) initiates signaling cascades leading to B cell activation, proliferation and differentiation. Signal transduction downstream of the BCR depends on the adaptor ... -
The membrane IgE tail imparts unique signaling properties to the B cell antigen receptor
(2017-10-23)Robust memory antibody responses are a distinguishing feature of humoral immunity and are typically marked by elevated serum immunoglobulin (Ig) titers that rapidly and effectively neutralize the invading pathogen. However, ... -
Unraveling details of CIN85/CD2AP assistance to SLP65-mediated B cell activation
(2020-06-18)The hallmark of adaptive immunity is the production of specific antibodies. This process is initiated upon the ligation of the B cell antigen receptor (BCR) which activates multiple intracellular signaling cascades through ... -
Vav guanine nucleotide exchange factors control B cell antigen receptor-induced Ca2+-signaling
(2016-03-15)Differentiation of B cells into antibody secreting plasma cells is an indispensable step to cope with pathogens. Antigen binding to the B cell antigen receptor (BCR) initiates signaling cascades leading in combination with ...