Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Referee "Daniel, Rolf Prof. Dr."
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A possible functional link between RNA degradation and transcription in Bacillus subtilis
(2020-09-24)Cellular levels of RNA depend on the rate of its synthesis and degradation. While synthesis is performed by RNA polymerase conserved in all domains of life, the enzymes responsible for RNA degradation are more unique ... -
A protein in search of a function: The c-di-AMP-binding protein DarA of Bacillus subtilis
(2019-07-26)Adaptation to changing environmental conditions is crucial for any organism to thrive in nature. Bacteria like the Gram-positive model organism Bacillus subtilis have evolved so-called second messengers to facilitate ... -
Clostridioides difficile: Analysis on Single Cell Motility and on Antibiotic Resistance
(2020-12-22)Clostridioides difficile, formerly in the genus Clostridium, is a Gram positive obligatory anaerobic spore forming bacterium. C. difficile is the leading nosocomial gastrointestinal pathogen in the western world. In ... -
Comparative systems biological analysis of the potential of a high-performance expression platform – Bacillus pumilus
(2023-06-29)This project was supported by the German Federal Ministry of Education and Research (BMBF) with the grant ID: Fkz.031B057 under the Industrial Biotechnology Innovation Initiative. The particular program corresponds to the ... -
Cyclic di-AMP homeostasis and osmoregulation in Listeria monocytogenes
(2019-04-05)The second messenger cyclic diadenosine monophosphate (c-di-AMP) is essential for most of the bacteria synthesizing the nucleotide. c-di-AMP is produced by diadenylate cyclases (DACs) and degraded by specific phosphodiesterases ... -
Identification of factors involved in cell wall homeostasis and tolerance towards quaternary ammonium compounds in Listeria monocytogenes by genomic adaptation
(2023-06-20)Listeria monocytogenes is one of the most successful food-borne pathogens worldwide. Despite available treatment with cell wall targeting antibiotics an infection with concomitant development of listeriosis results in death ... -
Investigation of prokaryotic immune defense system with quantitative and structural mass spectrometry
(2016-02-26)Bacteria and archaea have evolved an adaptive and heritable immune defense system comprising a CRISPR (clustered regularly interspaced short palindromic repeats) locus and Cas (CRISPR-associated) proteins that targets ... -
Novel approach for identification of biocatalysts by reverse omics techniques
(2019-08-06)A novel screening approach for identification of biocatalysts by reverse omics techniques was developed. Basic principle is the differential analysis of metatranscriptomes obtained from cultures treated either with the ... -
Protein Interactions in minimal cells
(2022-05-18)Minimal cells are used to model and understand life’s complex processes. The most essential processes of life are thought to include cell replication, energy metabolism and genome maintenance. However, construction of a ... -
Proteomic Profiles of Campylobacter jejuni and Enterococci during Co-incubation and under Bile Acid Stress
(2023-11-03)The human gut harbors a complex ecosystem of microbial communities, consisting of commensal inhabitants, which play crucial roles in maintaining gut homeostasis, regulating host metabolism, and modulating immune responses. ... -
Structure and function of bacterial viruses and viral communities
(2023-03-16)Bacterial viruses, known as bacteriophages or phages, are the most abundant biological entities on the planet and the least studied in terms of abundance and diversity. Searching the sequence databases of viral genomes, ... -
The Zinc cluster transcription factor ZtfA is an activator of asexual development and secondary metabolism and regulates the oxidative stress response in the filamentous fungus Aspergillus nidulans
(2018-06-11)The interconnection of developmental programs and secondary metabolism is regulated by the velvet domain proteins in numerous filamentous fungi. Velvet domain proteins constitute a family of fungal specific transcription ... -
Validation of novel protein-protein interactions in Bacillus subtilis
(2023-01-12)Protein-protein interactions are the basis for many biological processes in the cell. Understanding these interactions is crucial for the general analysis of how the cell functions and the potential identification of ... -
Vitamin B6 metabolism and underground metabolic routes in the Gram-positive bacterium Bacillus subtilis
(2021-07-16)Genome-reduced bacteria give the opportunity to study essential gene functions but also give the starting point for biotechnological production pathways. The MiniBacillus project aims to produce a genome reduced Bacillus ...