Dokumente GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften nach Gutachter "Dobbelstein, Matthias Prof. Dr."
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A Mitotic Actin Regulating Pathway Induces Chromosomal Instability In Human Cancer Cells
(2020-06-11)Chromosome instability (CIN) is a hallmark of human cancer and causes structural (S-CIN) as well as whole (W-CIN) chromosome aberrations. Cancers exhibiting the CIN phenotype are characterized by a large genetic heterogeneity ... -
A novel function of DPP9 in DNA damage repair via BRCA2 regulation
(2019-01-25)Eukaryotic cells are constantly exposed to exogenous and endogenous agents that induce mutational stresses in their genome, which can lead to genetic lesions, such as chromosome loss, translocations or deletions. The ... -
A novel phosphatase modulating the DNA damage response and the tumor suppressor p53
(2011-09-21)The cellular genome is constantly exposed to harmful endogenous and exogenous factors. Unrepaired DNA lesions and mismatches promote genomic instability, a major cause of cancer. Therefore, ... -
Analysis of the transcriptome of human NK lymphocytes
(2016-10-31)Natural Killer cells are large granular lymphocytes that contribute to both innate and adaptive immunity, as they can not only lyse infected cells or tumors, but also stimulate an adaptive immune response via production ... -
Bioinformatics analysis of multi-omics data elucidates U2 snRNP function in transcription
(2021-08-16)Transcription by RNA polymerase II (Pol II) is an important step in cell function and regulation. Pol II transcription has been shown to be coupled to pre-mRNA splicing, but the underlying mechanisms remain poorly ... -
Characterization of the retinoic acid-induced gene network responsible for pancreas specification in Xenopus laevis
(2017-02-06)Retinoic acid (RA) is critically required for pancreas specification in Xenopus and other vertebrates. However, the gene network that is directly induced by RA-signaling in this context remains to be defined. We identified ... -
Combining gemcitabine with checkpoint kinase inhibitors to sensitize pancreatic tumors
(2015-04-15)Pancreatic tumor is one of the leading causes of cancer-related deaths in the world. Currently, the nucleoside analogue gemcitabine is the leading therapeutic drug for the treatment of pancreatic tumors. However, due to ... -
Cooperation of p300 and iASPP in apoptosis and tumour suppression
(2014-11-04)Mutation or functional inactivation of tumour suppressors represents a key event in the transformation of cells and contributes to the development of cancer. P300 and CBP constitute two histone acetyltransferases with ... -
Dissecting the molecular mechanism and spatiotemporal dynamics controlling senescence entry
(2021-01-21)Senescence represents a programmed cell cycle arrest against aberrant proliferation and tumour development due to accumulated genotoxic or metabolic stress. The tumour-suppressive properties of senescence attracted the ... -
Drug Metabolism Determines Resistance of Colorectal Cancer to Resorcinol-Based HSP90 Inhibitors
(2014-11-04)Tumor cells are characterized by intrinsic proteotoxic stress and the accumulation of mutated proteins. Therefore, malignant cells depend on the activity of heat shock protein 90 (HSP90) much more than normal cells to ... -
Epigenetic regulation of osteoblast differentiation
(2017-06-07)Proper temporal epigenetic regulation of gene expression is essential for cell fate determination and tissue development. However, epigenetic mechanisms involved in control of bone-specific transcriptional programs remain ... -
Epigenetic Regulation of Tumor Cell Phenotype
(2017-04-03)The Transforming Growth Factor-β (TGFβ)/SMAD signaling pathway can function as either a tumor suppressor or metastasis promoter during tumor progression. In normal epithelial cells and early stages of epithelial ... -
Functional characterization of transketolase-like proteins and related model systems with respect to thiamin diphosphate mediated chemistry
(2014-11-12)Transketolases (TKTs, E.C 2.2.1.1) are ubiquitous distributed enzymes among all three domains of life. TKTs require thiamin diphosphate (ThDP) and bivalent cations as catalytic cofactors. They fulfill their catalytic ... -
Gemcitabine Resistance Elicits a Calcium Dependent Epigenetic Reprogramming in Pancreatic Cancer
(2021-03-08)Pancreatic cancer is a dismal malignancy with a 5-year survival rate of 7-9%, one of the worst among all cancer types. Patients with pancreatic ductal adenocarcinoma (PDAC) usually present an advanced stage of the disease ... -
Identification of therapeutic targets in the Burkitt’s lymphoma specific B cell antigen receptor signaling network
(2018-11-12)Burkitt’s lymphoma (BL) is an aggressive B cell neoplasm that is characterized by a chromosomal translocation, which brings the proto-oncogene c-MYC under the control of Immunoglobulin (Ig) enhancer elements leading to ... -
Investigation of the role of microtubule dynamics in paracrine signaling and cell invasion in human cancer cells
(2021-09-23)Metastasis is a critical characteristic of aggressive human cancer, which is determined by the acquirement of increased cancer cell migration and invasion capabilities. Recent published work indicated that supernumerary ... -
MDM2 as a chromatin modifier
(2020-09-08)Since its discovery about 40 years ago, the transcription factor p53 has turned into the most extensively studied protein in the context of human cancers due to its essential role in promoting tumor suppression. P53 ... -
Mechanisms underlying age-related decline in mammalian female fertility
(2024-03-05)Reproductive longevity is crucial for fertility and impacts healthy ageing. Unlike in men, fertility in women starts to decline several decades before other signs of ageing set in. Female fertility is restricted by a limited ... -
Multi-omics studies of transcription regulatory mechanisms during human cell fate transition
(2024-02-16)RNA polymerase II (Pol II) transcription is an essential process in living organisms that requires accurate regulation and coordination in order to produce protein-coding and many types of non-coding transcripts. One of ... -
Role of 5-FU in DNA double strand break repair for improved targets in colorectal cancer therapy
(2015-04-14)Colorectal cancer (CRC) is the second leading cause of cancer related deaths in the world, and 5-Fluorouracil (5-FU) based regimens are chiefly employed for its therapy. Modern regimens, based on 5-FU in combination with ...