Dokumente GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften nach Gutachter "Dresbach, Thomas Prof. Dr."
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A guardian of balance: the role of BAF chromatin remodeling complex in astrogliogenesis during mouse forebrain development
(2019-12-20)In the human central nervous system, astrocytes vastly outnumber neurons and regulate a host of physiological processes critical to its function. Astrocytes form a functional syncytium tiling the brain with minimal overlap ... -
Activity-based automatic ROI generation (AARG) analysis of dendritic spine calcium transients reveals distance-dependent activity of voltage-gated calcium channels
(2018-03-20)Imaging synaptic activity in the form of calcium transients occurring in dendritic spines is advancing our understanding of nerve cell function beyond what can be achieved using electrophysiological methods alone. I have ... -
Changes in gene expression linked to Alzheimer's disease and "healthy" cognitive aging
(2019-02-20)Alzheimer’s disease (AD) is a neurodegenerative disease and the most common form of dementia. The number of AD cases increases exponentially every year. Although AD has been investigated for a long time, the precise ... -
Characterization of FBXO7 (PARK15) knockout mice modeling Parkinsonian-Pyramidal Syndrome
(2017-04-19)The second most common neurodegenerative disease, Parkinson’s disease (PD), is caused by loss of dopaminergic neurons in the substantia nigra leading to impaired motor control. Genetic analyses have revealed recessively ... -
Cortical patterning and neuronal migration are under the guide of BAF complex functionality
(2020-03-26)The brain is one of the complex organs designed under the control of a plethora of molecular and cellular regulatory mechanisms, including transcriptional and epigenetic pathways. Brain organogenesis proceeds in a stepwise ... -
Dual-AAV mediated transfer of full-length otoferlin cDNA into auditory inner hair cells and the effects of different mutations in the OTOF gene on the protein levels and cellular distribution of otoferlin in auditory inner hair cells
(2019-05-08)Otoferlin is a large multi-C2 domain protein indispensable for hearing and synaptic transmission in auditory inner hair cells (IHCs). Mutations within the OTOF gene, coding for otoferlin, cause non-syndromic recessive ... -
Electrophysiological Analysis of the Synaptic Vesicle Priming Process
(2017-08-17)Chemical synaptic transmission is the most prominent communication channel employed by neural circuits. It is initiated by the action potential triggered fusion of transmitter-filled synaptic vesicles with the presynaptic ... -
Excitation-Secretion Coupling of Dense-Core Vesicle Release
(2023-07-18)Dense-core vesicles (DCVs) are membrane-bound organelles present in many secretory cells. Depending on cell type, DCVs package and release various types of cargo, such as neuronal peptides, proteins, neurotrophins, ATP, ... -
Functional Analysis of E3 Ubiquitin Ligases in Developing Neurons
(2019-08-15)Neuronal development starts after the closure of the neural tube when neural stem cells begin to divide asymmetrically at the ventricular zone of the forebrain. Newborn neurons then migrate vertically from the ventricular ... -
Illuminating the Morphological and Functional Plasticity of the Cochlear Inner Hair Cell Ribbon Synapse
(2023-10-24)Sound detection occurs in the cochlea, where sensory inner hair cells (IHC) accurately convert auditory stimuli into a neurochemical signal. Presynaptically, cochlear IHCs harbor highly-specialized electron-dense specializations ... -
Investigation of Vesicle Pool Dynamics at Activity Modulated Inner Hair Cell Ribbon Synapses
(2018-01-18)The inner hair cell ribbon synapses are the relay stations of the auditory pathway, attuned to transmit acoustic information at rates of up to hundreds of Hz. Such indefatigable signal transmission demands ultrafast vesicle ... -
Mechanisms underlying the temporal and selective induction of Ptf1a target genes
(2019-01-30)The bHLH transcription factor Ptf1a is crucial for the generation of a GABAergic neuronal cell fate over an excitatory glutamatergic fate. Ptf1a is a component of a heterotrimeric transcription factor complex, which in ... -
Molecular Mechanisms Involved In The Generation Of Inhibitory Postsynaptic Structures
(2021-07-07)In the work presented here, a set of full-length size-selected and unamplified cDNA expression libraries [30.000 CFU in total; size-fractionated into 2-3, 3-4, and 4-5 kb pools of 10.000 CFU each] was screened for proteins ... -
Molecular physiology of signal transmission along the auditory pathway
(2017-12-13)Signal transmission lies at the core of brain function. Understanding how information is transferred from one neuron to the other is the first step toward deciphering not just normal brain processing but the pathology of ... -
Molecular physiology of sound encoding
(2021-10-26)Inner hair cells (IHC) are responsible for transforming mechanical sound-borne vibrations into electrical signals and conveying this information to the afferent spiral ganglion neurons (SGNs). Upon stimulation, the receptor ... -
Molecular physiology of synaptic sound encoding at the first auditory synapse
(2018-03-20)To achieve accurate encoding of sounds, inner hair cell (IHC) ribbon-type synapses are highly specialized to release synaptic vesicles (SVs) with high rates and temporal precision. A sophisticated, by far not yet fully ... -
Molecular studies of the synaptic protein otoferlin
(2017-02-24)Deafness is an interesting and intensely studied topic and can be caused by different, genetic as well as environmental, factors. One important cause of deafness are mutations in the otoferlin gene leading to non-syndromic ... -
Morphological Studies of Synaptic Vesicle Recycling at the Inner Hair Cell Ribbon Synapse
(2020-01-10)Within the mammalian inner ear, sensory inner hair cells (IHCs) of the organ of Corti are required to transduce sound waves into electrical signals. Specialized synapses at the IHC basal pole, so-called ribbon synapses, ... -
Multi-omic analysis of the aging mouse brain
(2021-12-23)Brain function is highly dependent on a well-regulated, harmonic interaction of a multitude of cellular and molecular pathways. During aging, many of these pathways undergo progressive changes, leading to gradual deterioration ... -
Pathophysiological effects of Beta-Synuclein mutants P123H and V70M
(2023-07-24)Mutations in the beta-synuclein protein have been directly linked to Dementia with Lewy bodies (DLB). In particular, P123H mutation was linked to a familial case of DLB, whereas V70M mutation was identified in a sporadic ...