Dokumente GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften nach Gutachter "Enderlein, Jörg Prof. Dr."
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A Minimal Approach to the Dynamic Regulation of Biomolecular Conformation
(2022-12-14)Allostery is the key mechanism enabling a “remote” regulation of the activity of proteins and other biological macromolecules. It forms the basis for controlling various inter- and intracellular processes. Allosteric ... -
Active and Passive Microrheology of F-Actin Membrane Composites
(2018-07-19)The complex mechanical properties of a living cell are not only a function of its structural components but also of the organizational super-structure and the dynamic interconnection of filaments, proteins and the plasma ... -
Advances in enhanced multi-plane 3D imaging and image scanning microscopy
(2021-01-07)High-speed 3D optical microscopy is an indispensable requirement in studying rapid processes like signaling in neuronal networks, flagellar motion, or complex motion of living and highly dynamic subcellular components. ... -
Cellular dynamics and stable chaos in balanced networks
(2016-01-22)A prudent approach to understanding the function of the cerebral cortex begins with understanding the repertoire of its dynamics. In this thesis, I study how interactions between single neuron properties, synaptic coupling, ... -
Chaotic Neural Circuit Dynamics
(2018-02-09)Information is processed in the brain by the coordinated activity of large neural circuits. Yet, we are still only starting to understand how this high-dimensional complex system gives rise to functions such as processing ... -
Collective Behaviour of Filamentous Cyanobacteria
(2024-01-11)Cyanobacteria are the oldest phototrophic organisms on the planet. Having been responsible for the “Great Oxidation Event” millions of years ago, it has enabled the development and sustenance of multi-cellular life forms, ... -
Complex Structure and Dynamics of the Heart
(2013-10-02)Excitable media are a class of spatially extended biological and chemical systems, which display a characteristic type of pattern formation by supporting the propagation of nonlinear excitation waves. In the heart, plane ... -
Conformational Changes in Ligand Binding Processes
(2015-03-11)Ligand and protein-protein binding processes play a crucial role in many biological processes. In many cases ligand binding is associated with conformational changes within the receptor protein. While structure determination ... -
Constitutive Modeling for Tissue Engineered Heart Repair
(2020-10-27)Computer-aided therapy design is an intricate endeavor intertwining all scales from molecules to cells and tissues to organs. Changing one such component in a living system can have far-reaching effects, diffcult to ... -
Cotranslational folding of HemK C-terminal domain
(2023-03-17)The correct folding of proteins is essential for the survival of the cell. Despite the importance of the question, it remains largely unclear how proteins, in particular large multidomain proteins with mixed α-helical and ... -
Curvotaxis and Pattern Formation in the Actin Cortex of Motile Cells
(2015-12-09)Amoeboid cell migration is a crucial part of life. Neutrophil granulocytes, a kind of phagocytes of the mammalian immune system, migrate from blood vessels through tissue towards spots of inflammation. To find this ... -
Development of new methods in fluorescence microscopy
(2015-12-02)In recent years, advancements in single-molecule imaging techniques have enabled scientists to study in great detail the cells and relevant physiological processes, including neurons and the communication between them. ... -
Drift and stabilization of cortical response selectivity
(2021-08-02)Synaptic turnover and long term functional stability are two seemingly contradicting features of neuronal networks, which show varying expressions across different brain regions. Recent studies have shown, how both of these ... -
Dynamic Temperature Mapping - Real-time Strategies and Model-based Reconstructions
(2017-02-09)The purpose of this thesis was to explore the potential of real-time MRI methods for temperature mapping during thermal procedures. This mainly included a comprehensive analysis of two different methods, i.e. proton resonance ... -
Dynamics and mechanics of adherent cells in the context of environmental cues
(2015-03-25)Cellular behavior is influenced by many biochemical but also physical factors in the direct cellular environment. Thereby, cells not only react to external cues, the interaction between cells and their environment is also ... -
Dynamics and self-organization of membrane-bound minimal actin and actomyosin cortices based on ezrin-PtdIns[4,5]P2 linkage
(2022-11-22)The cellular cortex is a thin actin layer attached to the cytoplasmatic plasma membrane leaflet of mammalian cells. Through a complex interaction with hundreds of actin binding proteins (ABPs), controlling e.g. the cortex ... -
Electrical Control of Droplet formation in Microfluidic Devices
(2014-09-23)This thesis presents both experimental investigations and demonstration on the use of an AC voltage induced electric field to actively control the size or frequencies of droplet generated in a microfluidic flow focusing ... -
Extending Resolution in All Directions: Image Scanning Microscopy and Metal-induced Energy Transfer
(2019-03-18)Fluorescence microscopy is a powerful tool in the life sciences and is used to study structure and function on length scales from cells down to single molecules. In recent years, fluorescence microscopy has seen enormous ... -
Fluorescence Lifetime Single Molecule Localisation Microscopy
(2021-03-26)In conventional fluorescence microscopy, species are distinguished by colour. While these images provide an abundance of information about the sample, they are, in many aspects limited by artefacts and resolution, and some ... -
Forces in Cellular Growth and Division
(2016-02-05)Under confinement cell populations exert growth forces onto their surroundings. Confined cell populations can be found plentiful in nature, e.g. tumors embedded in healthy tissues, microbial populations in stone cavities ...