Dokumente GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften nach Gutachter "Flügel, Alexander Prof. Dr."
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Analysis of autoimmune lesions in grey matter
(2018-06-14)In the present thesis I demonstrated that pathogenic TβSyn cells of wild-type and receptor-transgenic origins could be reliably generated and used for inducing passive transfer EAE; active EAE could be reproducibly induced ... -
Characterization of immune responses in the meninges
(2022-06-14)Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS), which is characterized by plaque-like demyelination in both white and grey matter and diffuse neurodegeneration. A T cell-driven ... -
Crosstalk between the lung microenvironment and CNS autoimmunity
(2023-05-08)The contribution of the lung in shaping CNS autoimmunity is gaining relevance in the last years. Central nervous system (CNS) reactive T cells can acquire in the lung the potential to invade the CNS in experimental ... -
Effects and inducers of autoantibodies against N-methyl-D-aspartate (NMDA) receptors
(2020-03-20)Autoantibodies against the IgG class of N-methy-D-aspartate-receptor subunit GluN1 (NMDAR1-AB) were believed to cause anti-NMDAR encephalitis. However, the view was chanllenged by the finding of age-dependent seroprevalance ... -
Elucidating the mechanisms of disease-triggering myelin-specific autoantibodies
(2019-10-24)Although T cells are commonly known to be the driving force of disease pathogenesis in multiple sclerosis (MS) and its animal model experimental autoimmune encephalomyelitis (EAE), B cells and their soluble effector molecules ... -
Endocrine control of T cell function and its implications for the pathogenesis of neuroinflammatory diseases
(2013-06-17)Insulin and GCs are two important endocrine regulators of mammalian body homeostasis and both impact on immune cell functions. Whereas GCs are in widespread use for the treatment of autoimmune diseases since the late 1950s, ... -
Epigenomic and transcriptomic analysis of developing, adult and aging brain: mechanisms of brain folding, neuronal function and finding novel therapy for dementia
(2021-10-13)Histone modifications and gene expression are tightly regulated processes in the brain that has been shown to play crucial role from the beginning of brain development, learning-memory formation and aging. While brain ... -
Evaluating the function of the Aryl Hydrocarbon Receptor in CNS autoimmunity
(2018-12-07)The aryl hydrocarbon receptor (AhR) is a ligand activated transcription factor highly expressed within the immune and nervous system. Structurally diverse endogenous and synthetic ligands activate AhR, including dietary, ... -
In vivo approach to myelin turnover and oligodendrocyte-dependent axonal integrity
(2018-10-15)Deletion of the most abundant protein of CNS myelin, proteolipid protein (PLP) causes type 2 spastic paraplegia (SPG2) in humans, which is characterized by axonal degeneration. The assumption that the primary cause of SPG2 ... -
Pathophysiological Characterization of intra‐ and extracellularly aggregated Amyloid Peptides in Dementias
(2013-06-28)Alzheimer’s Disease (AD) is the most common form of dementia in the elderly population and is neuropathologically characterized by hippocampal neurofibrillary degeneration, chronic inflammation as well as widespread ... -
Role of microglia in myelin turnover
(2016-07-11)During development oligodendrocytes in the central nervous system (CNS) produce large amount of membrane to generate myelin which wraps around the axons. The synthesis, maintenance and turnover of such enormous amounts of ... -
Schwann cell differentiation in Charcot-Marie-Tooth disease 1 A (CMT1A)
(2019-04-11)Charcot–Marie–Tooth disease is the most common inherited neuropathy and a duplication of the peripheral myelin protein 22 gene (PMP22) causes the most frequent sub-form Charcot–Marie–Tooth 1A (CMT1A). In contrary to the ... -
The molecular mechanisms of myelin disassembly
(2016-08-26)Myelin is characterized by stacking of multiple layers of membrane compacted by MBP. The breakdown of myelin is a pathological hallmark of several autoimmune diseases of the nervous system. To assess the myelin fragmentation ... -
The role of the lung in shaping CNS autoimmunity
(2019-10-24)The lung was recently identified as a central site of T cell reprogramming in experimental autoimmune encephalomyelitis (EAE), a rodent model of multiple sclerosis (MS). While residing in the pulmonary tissue, central ...