Dokumente GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften nach Gutachter "Göpfert, Martin Prof. Dr."
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A Functional Characterisation of Drosophila Chordotonal Organs
(2013-06-27)Functional properties of the Drosophila FCO (femoral chordotonal organ) can be dissected by use of the Gal4-UAS system in combination with transcuticular in vivo Calcium imaging. As sinusoidal stimulation at relative ... -
Analyzing receptor responses in the Drosophila Johnston's organ with two-photon microscopy
(2017-07-31)Hearing organs rely on force-gated ion channels to convert the mechanical energy imposed by sound into receptor potentials usable by the nervous system. So far, little is known about the identity and working mechanisms of ... -
Biophysical and molecular mechanisms of mean and variance adaptation in the Drosophila ear
(2023-05-16)Adaptation is an important mechanism found across sensory systems and species. This important ability of sensory systems expands our range of perception. Giving us the ability to perceive a quiet whisper as well as a loud ... -
Biophysical modeling of information processing in the <i>Drosophila</i> olfactory system
(2014-04-24)Fruit flies (Drosophila melanogaster) rely on their olfactory system to process environmental information. Although extensive studies have helped neurobiologists to understand the basic molecular and cellular mechanisms ... -
Cellular mechanisms of odor detection in the olfactory system of the red flour beetle Tribolium castaneum
(2015-10-26)Olfaction, the detection of odors is pivotal for insects, since it leads them to food sources or mating partners and triggers important behaviors. For the detection of pheromones, CD36-related sensory neuron membrane ... -
Characterization of distinct contrast- and luminance-sensitive pathways in the Drosophila visual system
(2020-02-03)Visual systems are capable of extracting relevant information from dynamically changing environments. This allows animals to locate objects, escape predators and collisions or estimate self-motion, among others. During the ... -
Context, circuit and modulation of courtship signal selection in Drosophila
(2023-03-23)Communication is multi-modal -- when we interact, we speak, gesticulate, and touch. However, the neural computations and circuits that select and coordinate these communication signals are unclear. We address this issue ... -
Decoding the Epigenome of Neuronal Networks in Health and Disease
(2019-05-27)Alzheimer’s disease (AD) is the most prevalent form of dementia that has vast emotional and economic implications in our society. There is no cure for this neurodegenerative disorder as the pathological changes occur years ... -
Developmental Studies of Appendage Patterning and Formation in Spiders
(2016-11-21)In the animal kingdom arthropods are unparalleled in species number and diversity. Especially their appendages show a great morphological diversity and are adapted for different purposes like feeding, walking, flying, ... -
Expression and function of Rab3 interacting molecules and clarin-1 in inner hair cells
(2013-09-04)Hearing depends on faithful synaptic transmission at the inner hair cell (IHC) ribbon synapse, which is orchestrated by active zone proteins. RIM (Rab3 Interacting Molecules) is one of the active zone proteins and proposed ... -
Gene Ontology-based framework to annotate genes of hearing
(2013-10-22)As the number of discovered deafness genes and our knowledge about their role in hearing continuously increases, the need to accurately manage this genetic information is becoming more apparent. Gene Ontology (GO) is a ... -
Identification of the molecular changes underlying head morphology variation in closely related Drosophila species
(2016-09-09)The great diversity of adult morphologies that we can observe in nature is the product of millions of years of evolution of the underlying developmental programs. The genes that code for the transcription factors and ... -
In vivo approach to myelin turnover and oligodendrocyte-dependent axonal integrity
(2018-10-15)Deletion of the most abundant protein of CNS myelin, proteolipid protein (PLP) causes type 2 spastic paraplegia (SPG2) in humans, which is characterized by axonal degeneration. The assumption that the primary cause of SPG2 ... -
Information processing in the olfactory system of different amphibian species
(2020-09-29)General similarities of the olfactory system from insects to mammals make it tempting to extrapolate from one species to the other. However, the olfactory system is remarkably adaptive and diversified among animal lineages ... -
Intercellular Coordination in Epithelial Morphogenesis
(2022-07-26)During the development of an embryo, tissue rearrangements are driven by the precisely coordinated activity of thousands of cells. How this high degree of organization is achieved and regulated is one of the most important ... -
Linking senses: the genetics of Drosophila larval chordotonal organs
(2018-08-06)Sensory systems have evolved in all organisms to detect changes in the environment or their internal state. Even though they are essential for fitness and survival, their phylogenisis is still unclear. The protosensory ... -
Mechanical Properties of the lch5 Organ in the Drosophila Larva
(2017-09-08)I begin with a brief account of the topic of mechanosensation, followed by an outline of how the project evolved. The experimental techniques used and their rationale are described. The section ends with a short description ... -
Molecular physiology of sound encoding
(2021-10-26)Inner hair cells (IHC) are responsible for transforming mechanical sound-borne vibrations into electrical signals and conveying this information to the afferent spiral ganglion neurons (SGNs). Upon stimulation, the receptor ... -
Molecular studies of the synaptic protein otoferlin
(2017-02-24)Deafness is an interesting and intensely studied topic and can be caused by different, genetic as well as environmental, factors. One important cause of deafness are mutations in the otoferlin gene leading to non-syndromic ... -
Network formation and reorganization of the olfactory system of Xenopus laevis
(2022-03-03)The olfactory system is a window to the chemical world, that permits each species to adapt to novel spaces and situations. Despite the various phylogenetic adaptations, this sensory system maintains similar functional and ...