Dokumente GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften nach Gutachter "Groot, Bert de Prof. Dr."
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Accessing the kinetics of the supra-tauc range via relaxation dispersion NMR spectroscopy
(2013-10-30)Nuclear Magnetic Resonance spectroscopy (NMR) is capable of attaining dynamic information of motions over a broad range of time scales under physiological relevant conditions while maintaining atomic resolution. Of the ... -
Collective Dynamics Underlying Allosteric Transitions: A Molecular Dynamics Study
(2013-01-15)In all living cells, proteins are performing a vast amount of functions. These functions are often controlled by a mechanism called allosteric regulation. In allosteric regulation, binding affinities in one site are ... -
Micromechanical Mass Correlation Spectroscopy for the Characterization of Nanoparticles and Biomolecular Complexes in Fluid
(2016-03-15)Despite the wide range of techniques for the analysis of sub-micrometer objects, label- free characterization of nanoparticles in solution still remains a challenge. Microme- chanical resonators with embedded fluidic ... -
On the Effect of Binding on Ubiquitin Dynamics
(2014-03-26)Protein-protein interactions play an important role in all biological processes. But the principles underlying these interactions are not yet fully understood. Ubiquitin is a small signalling protein that non-covalently ... -
Protein Structure Characterization by Solid-State NMR: Structural Comparison of Mouse and Human alpha-Synuclein Fibrils, Sparse 13C Labeling Schemes, and Stereospecific Assignment of Val and Leu Prochiral Methyl Groups
(2013-04-10)This thesis describes protein structure characterization by solid-state nuclear magnetic resonance (ssNMR), including structural investigation of mouse alpha-synuclein (maS) fibrils and the comparison to human apha-synuclein ... -
Structural insights into Arginine-Serine rich proteins and N-H spin-spin coupling constants
(2013-11-27)This thesis is constituted of two parts. In the first part of this thesis, I studied the structural phenomena of SR protein phosphorylation. The serine/arginine-rich (SR) protein family plays multiple functions in the whole ...