Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Referee "Heinrich, Ralf Prof. Dr."
Now showing items 1-20 of 36
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AAV-based gene therapy for axonal regeneration in a rat model of rubrospinal tract lesion
(2015-04-29)Spinal cord injury (SCI) is a devastating and largely irreversible clinical condition, which can lead to permanent sensory and motor functional disabilities. Worldwide, an estimated 2.5 million people suffer from SCI and ... -
An omics analysis of genetic sleep loss in C. elegans
(2020-11-24)Sleep is a state of consciousness that has persisted through evolution and has become a necessity for animal welfare. In humans sleep loss has been shown to be inextricably intertwined with poor health. The prevalence ... -
Cellular stress induces RIS dependent sleep and ALA dependent sedation via EGF receptor signaling in Caenorhabditis elegans
(2019-07-15)Why do we sleep? This question is still unsolved, although sleep is such a fundamental behavioral state in all organism with a nervous system. Several physiological mechanisms, like memory consolidation, metabolic waste ... -
Characterization of FBXO7 (PARK15) knockout mice modeling Parkinsonian-Pyramidal Syndrome
(2017-04-19)The second most common neurodegenerative disease, Parkinson’s disease (PD), is caused by loss of dopaminergic neurons in the substantia nigra leading to impaired motor control. Genetic analyses have revealed recessively ... -
Characterization of olfactory receptor gene expression in the olfactory epithelium of larval Xenopus laevis
(2011-02-09)Olfactory receptors comprise the largest multigene family of G protein-coupled receptors in organisms ranging from fish to primates and are the detectors of thousands of odorant molecules. ... -
Characterization of the CNS-specific F-box protein FBXO41 in cerebellar development
(2014-05-28)During neurodevelopment, processes like neurogenesis, neuronal migration and morphogenesis, as well as synaptogenesis determine the shape and function of the brain. All developmental events are highly coordinated by extrinsic ... -
Development of a versatile microfluidic platform to study the ionic mechanisms of vesicular neurotransmitter transporters
(2021-11-04)This thesis described the development of a novel, versatile microfluidic platform for studying the ionic mechanisms of vesicular neurotransmitter transporters in rodent synaptic vesicles (SVs). The level of filling of an ... -
Development of Methods for Cardiac Tissue Characterization Using Magnetic Resonance Imaging in Animal Models
(2024-09-26)Cardiovascular diseases (CVDs) are the primary cause of death and disability globally. The progression of CVDs is often associated with functional and structural alterations, including reduced myocardial contractility, ... -
Effects and inducers of autoantibodies against N-methyl-D-aspartate (NMDA) receptors
(2020-03-20)Autoantibodies against the IgG class of N-methy-D-aspartate-receptor subunit GluN1 (NMDAR1-AB) were believed to cause anti-NMDAR encephalitis. However, the view was chanllenged by the finding of age-dependent seroprevalance ... -
Effects of stress on the GABAergic system in the hippocampal formation and medial prefrontal cortex of the adult male rat
(2011-04-21)Stress facilitates the development of psychiatric disorders in vulnerable individuals. Previous studies have well documented the impact of stress on glutamatergic excitatory transmission ... -
Erythropoietin as a driver of neurodifferentiation, neuroplasticity and cognition – A continuum view of the neuronal lineage
(2019-12-05)Erythropoietin (EPO), named after its role in hematopoiesis, has been best studied in the hematopoietic system. Studies emphasizing the expression of EPO in the central nervous system have sparked an interest in its role ... -
Evaluation of genetic engineering and genome editing tools to develop multifactorial reproductive sterility or killing sperm systems for the improvement of the Sterile Insect Technique
(2020-11-20)Insects fulfill fundamental roles for the preservation of ecosystems such as pollination, but also represent key agricultural pests and human disease vectors accounting for immense economic losses and approximately one ... -
Evolution of central complex development: Cellular and genetic mechanisms
(2019-11-11)Brains are conserved between insect species, as they consist of a set of anatomically similar areas, or neuropils. Simultaneously, these neuropils differ in size, shape, position and developmental timing between insect ... -
From hearing to singing:sensory to motor information processing in the grasshopper brain
(2016-08-02)Grasshoppers, and among them especially the species Chorthippus biguttulus, have been used as a model system to study the neuronal basis of acoustic behavior. Auditory neurons have been described from intracellular recordings. ... -
GABA and glycine co-transmission in the developing mouse respiratory network
(2014-11-18)Inhibitory neurons in the pre-Bötzinger complex - a kernel for respiratory rhythm generation, are involved in the respiratory rhythm modulation. The co-transmission of GABA and glycine has been reported in different brain ... -
Genetic and autoimmune modulators of brain function in neuropsychiatric illness and health
(2018-06-15)In the present thesis, the synergetic interaction between the nervous and immune systems and the potential pathological outcomes mediated by autoimmune processes targeting the brain was addressed, with a particular focus ... -
Hemisphere and region - specific effects of chronic stress in the rat prefrontal cortex
(2007-05-03)This thesis demonstrated that pyramidal neurons of the prelimbic and infralimbic area of the rat prefrontal cortex had an intrinsic morphological asymmetry in that pyramidal neurons in the ... -
Identification and Analysis of Gene Product Modifiers of α-Synuclein Toxicity in the Fruit Fly (D. Melanogaster).
(2010-09-22)Parkinson s disease (PD) is a progressive neurodegenerative disorder, pathologically characterized by loss of dopaminergic neurons in the substantia nigra pars compacta. Various mutations ... -
Investigating post-translational modifications and novel interaction partners of otoferlin
(2019-10-30)Otoferlin is a large multi-C2-domain protein essential for hearing and fast Ca2+-triggered transmitter release from auditory IHCs. Mutations in the OTOF gene are linked to a form of autosomal recessive non-syndromic hearing ... -
Mechanisms of Neuroligin Function in Inhibitory Postsynaptic Differentiation
(2009-10-14)The establishment of accurate synaptic transmission underlies neural network processing and nervous system function. The organized deployment of specialized synaptic machinery is a key ...