Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Referee "Janshoff, Andreas Prof. Dr."
Now showing items 1-20 of 27
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Actin turnover regulates mechanical properties of oligodendrocytes and myelin formation
(2015-10-02)The myelin sheath is a specialized membranous structure that facilitates rapid signal conduction along axonal segments. During central nervous system development, it is formed by oligodendrocytes that extend motile and ... -
Active and Passive Microrheology of F-Actin Membrane Composites
(2018-07-19)The complex mechanical properties of a living cell are not only a function of its structural components but also of the organizational super-structure and the dynamic interconnection of filaments, proteins and the plasma ... -
Automated STED microscopy for cell-biological high-throughput assays
(2022-11-28)In the past decade, super-resolution fluorescence microscopy has revolutionized biological research by enabling the study of biological functions down to the molecular scale. Despite profound technological developments, ... -
Biogenesis and maintenance of cytoplasmic domains in myelin of the central nervous system
(2017-02-27)Myelin is a multi-lamellar membrane structure, produced by oligodendrocytes which are special glial cells, that myelinate axons in the central nervous system (CNS) (Aggarwal, Yurlova, & Simons, 2011; Vassall, Bamm, & Harauz, ... -
Cellular locomotion and adhesion in the context of different substrate properties
(2017-01-16)This work comprises three different projects dealing with the interplay of cellular locomotion and adhesion to establish a better understanding of the response of cells to their environment. In the first part of this thesis ... -
Collective Mechanical Behavior of Epithelial Cells - The Impact of Micro-Wounding
(2019-06-24)For epithelia, which are lining organs or blood vessels, the mechanical integrity of a whole cell sheet is indispensable. The question arises, how neighboring cells mechanically work together to build a functioning cell ... -
Combining force and fluorescence microscopy for the manipulation and detection of single cells, viruses, and proteins
(2014-10-13)Total Internal Reflection Fluorescence Microscopy (TIRFM) and Atomic Force Microscopy (AFM) are both successfully applied in biophysics and biology. AFM provides the possibility to image and to mechanically manipulate the ... -
Cortical Tension of Cells: From Apical Membrane Patches to Patterned Cells
(2018-12-05)During their lifetime, cells and tissues have to deal with a variety of mechanical challenges. Shear forces exist inside of vessels, bones have to carry the weight of organisms and connective tissues are generally deformed ... -
Dynamics and mechanics of adherent cells in the context of environmental cues
(2015-03-25)Cellular behavior is influenced by many biochemical but also physical factors in the direct cellular environment. Thereby, cells not only react to external cues, the interaction between cells and their environment is also ... -
Extending Resolution in All Directions: Image Scanning Microscopy and Metal-induced Energy Transfer
(2019-03-18)Fluorescence microscopy is a powerful tool in the life sciences and is used to study structure and function on length scales from cells down to single molecules. In recent years, fluorescence microscopy has seen enormous ... -
Forces in Cellular Growth and Division
(2016-02-05)Under confinement cell populations exert growth forces onto their surroundings. Confined cell populations can be found plentiful in nature, e.g. tumors embedded in healthy tissues, microbial populations in stone cavities ... -
Intermediate filament mechanics across scales
(2022-02-24)The mechanical properties of cells are largely determined by the cytoskeleton. The cytoskeleton is an intricate and complex structure formed by protein filaments, motor proteins, and crosslinkers. The three main types of ... -
Keratin Networks in Live Cells
(2014-09-26)Intermediate filaments are a major component of the eukaryotic cytoskeleton along with microtubules and microfilaments and play a key role in cell mechanics. One representative of this class of proteins, which exemplifies ... -
Mechanics and Dynamics of <i>Dictyostelium discoideum</i> adhesion
(2021-09-28)The amoeba Dictyostelium discoideum (D.d.) is an excellent laboratory model system for studying amoeboid adhesion. In its natural habitat, D.d. lives in the soil and hunts for bacteria, an environment, which ... -
Mechanics and Motility of Epithelial Cells: From Single Cell Behavior to Collective Migration
(2023-01-13)Mechanical behavior of cells plays a crucial role in a plethora of biological processes. Despite its importance, this aspect of life science has only more recently gained increasing interest. Yet, without mechanical force ... -
Membrane tension homeostasis of mammalian cells
(2017-04-12)Although a cell is the smallest unit that is viable on its own, its construction and processes are of great complexity. Many functions, which keep a cell alive, are only poorly understood up to now. Plasma membrane tension ... -
Molecular Details of Membrane Deformation by ENTH Domains
(2018-03-20)During clathrin mediated endocytosis (CME) cargo molecules are transported across the plasma membrane from the outer cell surface into the cytosol. In this process, the plasma membrane undergoes massive local remodeling ... -
Nanoscale organization and dynamics of SNARE proteins in the presynaptic membranes
(2015-10-19)The specific organization of proteins and lipids in functional domains in biological membranes allows localization and segregation of specific physiological activities. Mechanisms that underlie the formation of these domains ... -
Oscillatory instabilities of intracellular fiber networks
(2015-12-02)D. discoideum shares many common features of actin dynamics and essential responses with eukaryotic cells and cancer cells. Therefore, most properties of the oscillations are well studied in the simpler biological model ... -
Role of cellular dynamics, adhesion and polarity in the context of primordial germ cell migration in Xenopus laevis embryos
(2014-02-11)Directional cell migration is an intensively studied process relevant for both normal development of an organism as well as for a number of pathological conditions such as chronic inflammation and cancer. Primordial germ ...