Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Referee "Johnsen, Steven Prof. Dr."
Now showing items 1-8 of 8
-
Analysis of genetic interactions and hierarchies of Wnt-signaling components in vivo
(2013-02-13)In cooperation with other signaling cascades the Wnt/β-catenin signaling pathway is an essential regulator of embryonic development as well as adult tissue homeostasis and stem cell proliferation. Mutations in components ... -
CHARGE syndrome: candidate genes and pathogenesis
(2015-09-25)CHARGE syndrome is a complex malformation syndrome affecting several organ systems like the central nervous system, ear, eye and heart. Heterozygous loss of function mutations in CHD7, a conserved chromatin remodelling ... -
Epigenetic regulation of osteoblast differentiation
(2017-06-07)Proper temporal epigenetic regulation of gene expression is essential for cell fate determination and tissue development. However, epigenetic mechanisms involved in control of bone-specific transcriptional programs remain ... -
Identification of therapeutic targets in the Burkitt’s lymphoma specific B cell antigen receptor signaling network
(2018-11-12)Burkitt’s lymphoma (BL) is an aggressive B cell neoplasm that is characterized by a chromosomal translocation, which brings the proto-oncogene c-MYC under the control of Immunoglobulin (Ig) enhancer elements leading to ... -
Lysosomal and mitochondrial crosstalk: the role of lysosomal signaling on mitochondrial biogenesis and function
(2018-11-15)Defects in metabolism result in various diseases, with neurodegeneration being one of the most prevalent consequences. Mitochondria and lysosomes are long known to be fundamental for cellular metabolism. In addition to ... -
Microglia activation and regulation of remyelination in the central nervous system
(2019-08-21)In the central nervous system, remyelination requires the proliferation and migration of oligodendrocyte progenitor cells (OPCs) to the lesions, and the differentiation of OPCs into oligodendrocytes that remyelinate the ... -
Systematic analysis of heterochromatin modification readout
(2017-06-14)Modifications of the building units of chromatin - the histone proteins and DNA - direct the functional readout of the genome and are part of the so called “epigenome” (Fischle et al., 2003b; Kouzarides, 2007). Several ... -
The role and regulation of histone H2B monoubiquitination during tumorigenesis
(2014-05-23)Posttranslational histone modifications are recognized as important regulators of gene expression. One of them, the monoubiquitination of lysine 120 of histone H2B (H2Bub1), has diverse functions and is involved in gene ...