Dokumente GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften nach Gutachter "Johnsen, Steven Prof. Dr."
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Gemcitabine Resistance Elicits a Calcium Dependent Epigenetic Reprogramming in Pancreatic Cancer
(2021-03-08)Pancreatic cancer is a dismal malignancy with a 5-year survival rate of 7-9%, one of the worst among all cancer types. Patients with pancreatic ductal adenocarcinoma (PDAC) usually present an advanced stage of the disease ... -
Molecular and cellular mechanisms of glucocorticoids in the treatment of acute graft-versus-host disease
(2012-11-19)Haematopoietic stem cell transplantation (HSCT) is often the only curative therapy for haematopoietic malignancies and some inherited diseases of the haematopoietic system. A major side effect of HSCT and a cause of morbidity ... -
Molecular characterization of Mst77F and implication in Drosophila spermatogenesis
(2013-04-19)The mechanisms of spermatogenesis, in particular the process of postmeiotic spermatid maturation, are little understood. During this developmental stage massive molecular and morphological rearrangements occur and the major ... -
Myeloid cell-specific ablation of the mineralocorticoid receptor attenuates experimental autoimmune encephalomyelitis
(2013-02-12)The mineralocorticoid receptor (MR) plays an essential role in regulating fluid and electrolyte homeostasis. Amongst hematopoietic cells, also macrophages express the MR but, unlike kidney or colon, they do not co-express ... -
The Role of ARID1A in Oncogenic Transcriptional (de)Regulation in Colorectal Cancer
(2019-07-23)The deregulation of epigenetic modulation has been well established as a common occurrence in cancer. However, the extent of its involvement in the development and progression of cancer was underscored by genome- and ...