Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Referee "Löwel, Siegrid Prof. Dr."
Now showing items 1-10 of 10
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Circuit refinement in mouse visual cortex during development
(2019-02-01)Circuit refinement is an important developmental process ensuring correct wiring of synaptic connections. During circuit refinement, favorable connections are generated or strengthened while unfavored ones are weakened or ... -
Determination of the Dynamic Gain Function of Cortical Interneurons with distinct Electrical Types
(2017-04-25)In the living brain, individual neurons are constantly bombarded by thousands of synaptic inputs, which results in a fluctuating membrane potential. Neurons under such conditions are said to operate in a “fluctuation-driven ... -
Impact of stroke and enriched environment on visual cortical plasticity in mice and therapeutic interventions for rehabilitation
(2014-02-18)Stroke is a major cause of death and disability in industrialized countries. Cortical plasticity is crucial for recovery and rehabilitation after a stroke. The aims of the study were to investigate the impact of a ... -
Neuronal correlates of implicit learning in the mammalian midbrain
(2016-08-29)Filtering auditory information according to its relevance is critical to elicit the appropriate behavioral response. The relevance of a sound is not carried by the sound itself but rather assigned by the brain based on ... -
Order under the guise of chaos: functional neuroanatomy of the somatosensory "barrel" cortex of the reeler mutant mouse
(2016-05-13)Rodents possess an array of facial whiskers on either side of their snout, which they use to collect tactile information about their surroundings. In layer IV of the somatosensory cortex, individual whiskers are represented ... -
Roles of PSD-93 and environmental enrichment in cortical synapses
(2015-11-10)During neurodevelopment several structural, molecular and functional changes take place in the brain to promote its maturation. These changes occur at multiple levels, including changes in protein expression, in the strength ... -
Sound encoding in mutant mice with disrupted action potential generation
(2018-08-10)Auditory tasks like sound localization or speech recognition require reliable and temporally precise neuronal sound encoding. The neuronal code must accurately preserve signal properties such as intensity and timing. ... -
Super-resolution of PSD95 remodelling during synaptic plasticity
(2021-07-01)Strengthening and weakening of synapses are a fundamental information processing unit within the neuronal circuit of the brain. It has been shown that the most abundant scaffold protein of the postsynaptic density (PSD), ... -
Ultrastructural Characterization of The Output of VIP Expressing Interneurons in Mouse Barrel Cortex
(2017-11-15)Based on this preliminary result, a quantitative immunoelectron microscopy study was adopted to comprehensively characterize the output of VIP interneurons across the whole laminae of mouse barrel cortex. Using VIPcre/YFP ... -
Vision, cortical maps and neuronal plasticity in Bassoon and PSD-95 mutant mice.
(2014-03-21)Bassoon mutant mice (Bsn-/-) display a striking loss of synaptic ribbons in photoreceptor terminals, which impairs signal transduction through the retina (Altrock et al., 2003; Specht et al., 2007). Therefore we assessed ...