Dokumente GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften nach Gutachter "Neher, Erwin Prof. Dr."
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A post-synaptic forgetting mechanism controlled by synaptotagmin 3
(2018-05-03)Activity-induced regulation of surface post-synaptic receptor number is a well-known mechanism underlying synaptic plasticity, but the molecular machinery mediating this process is poorly understood. In a screen of ... -
Confocal Imaging of Calcium Signal and Exocytosis at Individual Hair Cell Synapses
(2013-12-17)Hearing over a wide range of sound intensities is thought to require complementary coding by functionally diverse spiral ganglion neurons (SGNs), each changing its firing rate only over a limited sub-range. The means for ... -
Electrophysiological Analysis of the Synaptic Vesicle Priming Process
(2017-08-17)Chemical synaptic transmission is the most prominent communication channel employed by neural circuits. It is initiated by the action potential triggered fusion of transmitter-filled synaptic vesicles with the presynaptic ... -
Expression and function of Rab3 interacting molecules and clarin-1 in inner hair cells
(2013-09-04)Hearing depends on faithful synaptic transmission at the inner hair cell (IHC) ribbon synapse, which is orchestrated by active zone proteins. RIM (Rab3 Interacting Molecules) is one of the active zone proteins and proposed ... -
Genetic Targeting and Analysis of Parvalbumin and VGLUT3 Expressing Inhibitory Interneurons
(2012-03-12)GABAergic interneurons are a highly diverse class of cell types that play essential roles in regulating the input/output behaviour of pyramidal neurons and of other interneurons. Thereby, ... -
Investigation of spatio-temporal coding in the olfactory bulb of larval Xenopus laevis using fast confocal imaging
(2009-12-04)The olfactory bulb (OB) is the only central processing station of the vertebrate olfactory system. It is assumed that odors are represented by a spatio-temporal code in the OB, with both ... -
Modelling chemical signalling cascades as stochastic reaction diffusion systems
(2007-07-24)The main objective of this work lies on the development and application of methods for the analysis of stochastic effects in spatially extended chemical signalling cascades. The chemical ... -
Molecular physiology of signal transmission along the auditory pathway
(2017-12-13)Signal transmission lies at the core of brain function. Understanding how information is transferred from one neuron to the other is the first step toward deciphering not just normal brain processing but the pathology of ... -
Molecular physiology of sound encoding
(2021-10-26)Inner hair cells (IHC) are responsible for transforming mechanical sound-borne vibrations into electrical signals and conveying this information to the afferent spiral ganglion neurons (SGNs). Upon stimulation, the receptor ... -
Molecular physiology of synaptic sound encoding at the first auditory synapse
(2018-03-20)To achieve accurate encoding of sounds, inner hair cell (IHC) ribbon-type synapses are highly specialized to release synaptic vesicles (SVs) with high rates and temporal precision. A sophisticated, by far not yet fully ... -
Mover affects a subpool of primed synaptic vesicles in the mouse calyx of Held
(2019-10-10)Neuronal communication is a complex process; synapses must be formed, neurotransmitter has to be released at precise time points and it has to be “sensed” by the receiving end of a synapse with an equal accuracy. In this ... -
Nanoscopy inside living brain slices
(2014-10-30)In order to understand how memory is processed and stored in the brain, it would be helpful to observe the ongoing memory processes in action. This is no easy task, however, if it is to be done at the synaptic level. It ... -
NEW COMPUTATIONAL METHODS FOR 3D STRUCTURE DETERMINATION OF MACROMOLECULAR COMPLEXES BY SINGLE PARTICLE CRYO-ELECTRON MICROSCOPY
(2009-04-22)In cryo-electron microscopy (cryo-EM) single-particle reconstruction, projection images of many first order structural identical copies of the specimen of interest are combined to recover ... -
On the mechanisms governing plasma membrane organization - a STED-FCS investigation
(2014-06-04)The plasma membrane is the barrier which localizes and separates life's processes from their external environment. Long described as a free standing two-dimensional fluid mosaic, the organization of the plasma ... -
Optical analysis of synaptic vesicle protein molecules during exo- and endocytosis using pH-switchable fluorescent probes
(2011-11-22)At conventional synapses of the central nervous system (CNS), fast synaptic transmission is mediated by the release of neurotransmitters (NTs) upon Ca2+-triggered synaptic vesicle (SV) ... -
Regulation des intrazellulären Transports durch UNC-50 und die GARP-Komplexes in C. elegans
(2010-12-02)Fast synaptic transmission at the neuromuscular junctions (NMJs) in C. elegans is mediated by the neurotransmitter acetylcholine which activates ligand-gated ion channels of the nicotinic ... -
Role of Munc13 Isoforms in Regulating Large Dense Core Vesicle Exocytosis in Chromaffin Cells
(2015-11-03)The process of vesicular exocytosis is a fast, tightly regulated and Ca2+-triggered event mediated by SNARE complex formation. Although it is known that factors like Munc18, Munc13 and CAPS are important in setting up ... -
Role of PSD-95 in synaptic maturation and visual cortex plasticity
(2014-08-29)PSD-95 belongs to the family of DLG-MAGUKs (Discs-large membrane-associated guanylate kinases), and it plays an important role in organizing postsynaptic signaling and synaptic transmission in excitatory synapses. The ... -
Sound encoding at the first auditory synapse
(2020-08-21)The inner hair cell (IHC) synapse, the first relay station of the auditory system, is able to encode sound with sub-millisecond precision and without any signs of fatigue (Matthews and Fuchs, 2010; Pangršicˇ et al., 2012; ... -
The mechanism mediating fast neurotransmitter release at the calyx of Held synapse
(2009-07-02)Fast and synchronous neurotransmitter release relies on the time course of calcium influx into the terminal, the availability of fusion competent vesicles and the proteins comprising the ...