Dokumente GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften nach Gutachter "Neumann, Heinz Prof. Dr."
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Biochemical Characterization and Engineering of L-asparaginases for Amino Acid Depletion Therapy of Acute Lymphoblastic Leukemia
(2014-06-25)The goal of the present work was to form a basis for the development of improved protein therapeutics against acute lymphoblastic leukemia (ALL). Bacterial L-asparaginases, in combination with other chemotherapeutics, are ... -
Interactions and functions of RNA-binding proteins
(2018-04-13)Alongside several well-known modifications in DNA and proteins, more than 100 different types of chemical modification are also found in cellular RNAs. RNA modifications can influence the secondary structure and interactions ... -
Investigation of Nucleosome Dynamics by Genetic Code Expansion
(2015-10-28)The DNA of eukarytic cells is compacted into a complex macromolecular structure called chromatin. Histones are the small structural proteins that form central octamers around which the DNA is wrapped to form the basic ... -
Kinetic models of sequential initiation events upon polysome formation
(2017-09-08)Polysomes are active protein-synthesizing units consisting of multiple ribosomes assembled along one mRNA. The frequency of ribosome loading on the mRNA defines the number of ribosomes per polysome, which is an important ... -
A Method for the Quantitative Analysis of Protein-Protein Interactions In Vivo
(2016-04-13)The function and activity of proteins is often modulated by other proteins they interact with. To understand cellular behaviour at the system level, a complete description of interactions among different proteins and the ... -
Monitoring the late events of translation initiation in real-time
(2016-10-19)In bacteria, translation initiation is promoted by three initiation factors (IF1, IF2 and IF3) and entails three distinct steps. First, the small ribosomal subunit (30S) recruits the initiation factors, initiator tRNA ... -
Ribosome Processivity and Co-translational Protein Folding
(2017-04-21)Synthesis of polypeptide chains on the ribosome occurs at a non-uniform rate. mRNA sequences translated at a high rate are interspersed by segments that lead to translational pausing. The rate of translation elongation is ... -
Structural and Functional Characterization of CRM1-Nup214 Interactions Reveals Multiple FG-binding Sites Involved in Nucleocytoplasmic Transport
(2015-09-09)Transport into and out of the nucleus occurs through nuclear pore complexes (NPCs) that are embedded in the nuclear envelope. NPCs are massive macromolecular complexes of around 125 kDa in vertebrates. Around 30 different ... -
Study Conformational Dynamics of Intrinsically Disordered Proteins by Single‐Molecule Spectroscopy
(2016-09-06)Intrinsically disordered proteins (IDPs) are proteins which lack a well-defined three- dimensional structure. The abundance and functional significance of IDPs has been recognized only recently. Due to their properties, ... -
The role of the FACT complex in differentiation of multipotent stem cells
(2017-04-27)Cellular differentiation is accompanied by dramatic changes in chromatin structure which are associated with the activation of lineage-specific transcriptional programs. Facilitates Chromatin Transcription (FACT) is a ...