Dokumente GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften nach Gutachter "Salditt, Tim Prof. Dr."
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Acto-myosin based mechano-sensitivity of cells - comparing human mesenchymal stem cells and differentiated cells
(2017-08-09)Within the last decades it was discovered that the cellular microenvironment plays an important role in cellular processes and cell fate can be directed by mechanical properties of the extracellular matrix (ECM), which can ... -
Alpha-synuclein aggregation: visualization by X-ray techniques and its modulation by iron
(2017-09-06)Parkinson’s disease (PD) is the second most common neurodegenerative disease worldwide. It’s a progressive disease that can be treated only symptomatically and its causes are still not fully understood. Two main factors ... -
Basic coding activities of populations of Xenopus laevis olfactory receptor neurons recorded with a fast confocal line illumination microscope
(2013-09-05)The olfactory system is able to sample a large odor space with only a limited number of olfactory receptor neurons (ORN) using so-called combinatorial coding. Here, different ORN classes exhibit a broad but specific odor ... -
Colloidal Probe Force Spectroscopy
(2021-10-26)This thesis demonstrates how colloidal probe force spectroscopy, in connection with reconstituted biological model systems and theoretical models, allows us to investigate and understand the behavior of a wide variety ... -
Diffusion and Flow on Microscopic Length Scales Studied with Fluorescence Correlation Spectroscopy
(2012-10-30)The physics of fluids on microscopic lengthscales is fundamentally different from the one governing macroscopic fluid phenomena. On lengthscales up to a few micrometer, inertial forces of small particles and fluid elements are ... -
Integrational modelling for molecular analysis in a CRISPR/Cas edited iPSC-cardiomyocyte model of Dilated Cardiomyopathy
(2023-07-05)Machine learning has shown promising results in the prediction and diagnosis of cardiac diseases. By analyzing large amounts of patient data, such as imaging, genomics, or molecular phenotyping data, machine learning ... -
Investigation of membrane fusion as a function of lateral membrane tension
(2017-09-21)Membrane fusion in native systems occurs on very short time scales and it has been proposed that lateral membrane tension of the presynaptic membrane is substantially increased to facilitate fusion. Proteins of the SNARE ... -
Processing of different sensory qualities in the olfactory bulb of Xenopus laevis studied by advanced line illumination microscopy
(2016-10-10)The olfactory system is renowned for its ability to sample and process a tremendously large odorant space. Lately, it has been shown that other sensory qualities such as temperature and pressure are detected in the ... -
SNARE-mediated membrane fusion on pore-spanning membranes – several fusion pathways analyzed by single-vesicle content release
(2021-01-08)The fusion of neurotransmitter filled vesicles with the presynaptic membrane is the key step in the neuronal signaling cascade and is mediated by soluble N-ethylmaleimide-sensitive factor attachment receptor proteins ...