Dokumente GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften nach Gutachter "Schild, Detlev Prof. Dr. Dr."
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Activity-based automatic ROI generation (AARG) analysis of dendritic spine calcium transients reveals distance-dependent activity of voltage-gated calcium channels
(2018-03-20)Imaging synaptic activity in the form of calcium transients occurring in dendritic spines is advancing our understanding of nerve cell function beyond what can be achieved using electrophysiological methods alone. I have ... -
Generation and analysis of T cell receptor transgenic rats to model CNS autoimmunity
(2014-01-27)Autoreactive T cells directed against CNS antigens seem to play an essential role at least in the initiation of multiple sclerosis. To improve our understanding about the function of pathogenic T cells in CNS autoimmunity ... -
Nanoscale probing of single synapse function and BDNF Cell-to-Cell transfer
(2016-12-22)Brain-derived neurotrophic factor (BDNF) is one of the key modulator/mediator molecules for synaptic plasticity in the adult nervous system and also coordinates neural development, survival, differentiation and axon growth ... -
Neuronal mechanisms of odor classification in the Drosophila antennal lobe: an optical imaging study
(2015-12-15)Drosophila senses diverse kinds of olfactory stimuli in the external environment. These stimuli are often not pure chemicals, but rather mixtures of many odorants. The fly olfactory system, however, needs to extract the ... -
Processing of different sensory qualities in the olfactory bulb of Xenopus laevis studied by advanced line illumination microscopy
(2016-10-10)The olfactory system is renowned for its ability to sample and process a tremendously large odorant space. Lately, it has been shown that other sensory qualities such as temperature and pressure are detected in the ... -
Quantitative analysis of Förster resonance energy transfer from spectrally resolved fluorescence measurements
(2010-08-25)A novel method for spectral analysis of Forster resonance energy transfer (FRET) signals is presented. This method provides a general solution for donor quenching and acceptor sensitization ... -
Redox imbalance and oxidative stress in Mecp2 deficient neurons
(2016-11-10)Rett syndrome is a neurodevelopmental disorder that primarily occurs in girls with a prevalence of 1:10.000–1:15.000 life births. The main genetic reasons of Rett syndrome are mutations in the methyl-CpG binding protein 2 ... -
Structural and functional characterisation of M/T cells using Ca2+ Imaging and Activity Correlation Imaging in dendritic networks of the developing Xenopus brain
(2016-12-19)Olfactory information collected in the nose is conveyed from the axon terminals of olfactory receptor neurons to the dendritic tufts of mitral/tufted (M/T) cells across glutamatergic synapses. These synaptic interactions ... -
The Processing and Storage of Information in Neuronal Memory Systems Across Time Scales
(2018-05-25)Humans and animals are able to store and recall information about past experiences across a variety of time scales. This process is accomplished by memory, which is implemented in the neuronal systems of the brain. These ... -
The role of α-neurexins in Ca<sup>2+</sup>-dependent synaptic transmission and plasticity
(2006-05-18)This project investigated novel aspects of the function of α-neurexins in neurotransmission and synaptic plasticity. Whole-cell patch-clamp studies on heterologous cells showed that neurexin ...