Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Referee "Schwappach, Blanche Prof. Dr."
Now showing items 1-20 of 26
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Interplay of proteins and lipids during endoplasmic reticulum-associated protein degradation
(2024-11-14)The endoplasmic reticulum controls lipid homeostasis due to its central role in lipid biosynthesis and its regulation. Aberrant lipid composition and membrane properties in the endoplasmic reticulum interfere with its ... -
Structural and Functional Investigations of Transmembrane Signaling Histidine Kinase Using NMR
(2022-11-04)Membrane proteins play a central role in biology as the gatekeepers of all cellular compartments. And transmembrane signaling through membrane bound kinases is a particularly important process for cellular adaptation to a ... -
Decoding and influencing mitochondrial inner membrane ultra-structure biogenesis
(2022-04-28)The Mitochondrion is a ubiquitous organelle known to be involved in a variety of vital cellular functions besides its central role in ATP synthesis such as, cellular metabolism, signalling and apoptosis. Dynamic in both ... -
Vimentin Intermediate Filament Softening - Recovery Behavior and Post-Translational Modifications
(2021-09-16)The capability of eukaryotic cells to resist large deformations, to transport intracellular cargo and to adapt the cell shape, for example during migration, depends on the cytoskeleton, a composite network of three types ... -
The Mediator kinase module: structural and functional studies in transcription regulation
(2020-10-15)Transcription of protein-coding genes occurs when RNA polymerase II (RNAPII) and general transcription factors (GTFs) assemble at genomic promoter regions, forming a transcription pre-initiation complex (PIC), which ... -
Optimization of tools for multiplexed super resolution imaging of the synapse
(2020-07-09)The synapse is the major site of neurotransmission in the brain. Even though the synapse has been extensively studied, artefact-free imaging tools are still necessary for its correct investigation. With the resolution of ... -
Unraveling details of CIN85/CD2AP assistance to SLP65-mediated B cell activation
(2020-06-18)The hallmark of adaptive immunity is the production of specific antibodies. This process is initiated upon the ligation of the B cell antigen receptor (BCR) which activates multiple intracellular signaling cascades through ... -
The roles of RNA helicases and other ribosome biogenesis factors during small subunit maturation
(2020-05-29)RNA helicases are a highly conserved family of proteins that act as RNA-dependent NTPases. These proteins contain a conserved helicase core consisting of two RecA-like domains that are responsible for unwinding or annealing ... -
The implication of Kv10.1 in the regulation of G2/M progression
(2020-05-19)Kv10.1, also termed Eag1 (Ether-a-go-go1), is a voltage gated potassium channel, initially thought to be expressed in the central nervous system. Prolonged or increased expression of Kv10.1 has been found in over 70% of ... -
Proximity and Affinity based Analysis of Cardiac Caveolin Protein Interactions
(2020-03-06)Background and Objectives: The Caveolin (CAV1-3) family contains a unique class of membrane integral proteins with cytosolic termini. CAV1 or CAV3 are essential components of the caveolar core complex, a disc-shaped ... -
Structural Studies on Transmembrane Signalling Mechanism of Histidine Kinase CitA
(2019-12-18)Perception of environmental changes and subsequent signal transduction are key aspects for the survival of an organism. In bacteria, two component systems (TCSs) consisting of a homodimeric receptor histidine kinase (HK) ... -
Microglia activation and regulation of remyelination in the central nervous system
(2019-08-21)In the central nervous system, remyelination requires the proliferation and migration of oligodendrocyte progenitor cells (OPCs) to the lesions, and the differentiation of OPCs into oligodendrocytes that remyelinate the ... -
Analysis of Protein Transport to the Inner Nuclear Membrane
(2019-07-10)The eukaryotic cell is divided into different compartments. The biggest compartment is the nucleus which is formed by one lipid bilayer folded into two membranes: the outer nuclear membrane (ONM) and the inner nuclear ... -
Molecular investigation of mitochondrial inner membrane morphology
(2019-06-03)The mitochondrial inner membrane (MIM) is highly curved and displays a complex but extremely organised ultrastructure. It is subdivided into two morphologically, topologically, as well as functionally, distinct compartments. ... -
The role of mammalian TRC40 in membrane-protein targeting and chaperoning
(2019-05-24)Tail-anchored (TA) proteins are distinguished from other membrane proteins due to their particular topology. The best-characterized pathway for the targeting of TA-proteins is the GET pathway in yeast or the TRC pathway ... -
Molecular Interactions between Neurons and Oligodendrocytes during Myelin Formation
(2019-04-23)Myelin is a multi-layered membrane wrapped around axons. It allows fast nerve conduction and provides the axon with trophic support. In the central nervous sys- tem (CNS), oligodendrocytes form multiple myelin sheaths. ... -
A novel function of DPP9 in DNA damage repair via BRCA2 regulation
(2019-01-25)Eukaryotic cells are constantly exposed to exogenous and endogenous agents that induce mutational stresses in their genome, which can lead to genetic lesions, such as chromosome loss, translocations or deletions. The ... -
Norepinephrine induces internalization of Kv1.1 in hippocampal neurons
(2017-08-08)Norepinephrine (NE), a catecholamine produced by dopamine β-hydroxylase, is released either as a hormone from the adrenal medulla into the blood, or as a neurotransmitter in the brain. Norepinephrine signaling serves as a ... -
Characterization of the Molecular Chaperone Get3
(2017-08-03)Proteins within the cellular environment are constantly challenged by environmental stress conditions that threaten their structure and function, and increase the risk of forming potentially toxic protein aggregates. Sudden ... -
Function of the INA complex in assembly of the mitochondrial oxidative phosphorylation system
(2017-07-11)The majority of cellular ATP is produced by the mitochondrial F1Fo-ATP synthase, also called complex V, which consists of nuclear- and mitochondrial-encoded subunits. In order to form a functional enzyme, its proteins ...