Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Referee "Wienands, Jürgen Prof. Dr."
Now showing items 1-20 of 26
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Analysis of genetic interactions and hierarchies of Wnt-signaling components in vivo
(2013-02-13)In cooperation with other signaling cascades the Wnt/β-catenin signaling pathway is an essential regulator of embryonic development as well as adult tissue homeostasis and stem cell proliferation. Mutations in components ... -
Analysis of mice deficient in late endosomal SNARE proteins VAMP8/endobrevin and Vti1b
(2007-01-29)Membrane fusion requires a synchronized interplay between several proteins that form the membrane fusion machinery. SNAREs are the central component of this fusion machinery. Cognate SNARE ... -
Autoimmune T cell - B cell interaction in experimental autoimmune encephalomyelitis
(2015-03-17)Although Multiple sclerosis (MS) and its animal model experimental autoimmune encephalomyelitis (EAE) are known as T cell-mediated autoimmune diseases, there is increasing evidence that B cells also play a critical role ... -
Biochemical characterization of presynaptic membrane protein complexes
(2017-09-13)At chemical synapses, synaptic vesicles, membrane-enclosed entities filled with neurotransmitters, undergo exocytosis at restricted areas of the presynaptic membrane called active zones (AZ). The core AZ proteins form a ... -
Characterization of olfactory receptor gene expression in the olfactory epithelium of larval Xenopus laevis
(2011-02-09)Olfactory receptors comprise the largest multigene family of G protein-coupled receptors in organisms ranging from fish to primates and are the detectors of thousands of odorant molecules. ... -
Crosstalk between the lung microenvironment and CNS autoimmunity
(2023-05-08)The contribution of the lung in shaping CNS autoimmunity is gaining relevance in the last years. Central nervous system (CNS) reactive T cells can acquire in the lung the potential to invade the CNS in experimental ... -
Effects and inducers of autoantibodies against N-methyl-D-aspartate (NMDA) receptors
(2020-03-20)Autoantibodies against the IgG class of N-methy-D-aspartate-receptor subunit GluN1 (NMDAR1-AB) were believed to cause anti-NMDAR encephalitis. However, the view was chanllenged by the finding of age-dependent seroprevalance ... -
Elucidating the mechanisms of disease-triggering myelin-specific autoantibodies
(2019-10-24)Although T cells are commonly known to be the driving force of disease pathogenesis in multiple sclerosis (MS) and its animal model experimental autoimmune encephalomyelitis (EAE), B cells and their soluble effector molecules ... -
Expression and properties of neuronal MHC class I molecules in the brain of the common marmoset monkey
(2009-11-13)Several recent studies have highlighted the important role of immunity-related molecules in synaptic plasticity processes in the developing and adult rodent brain. It has been suggested that neuronal MHC (major ... -
Functional Analysis of Heat Shock Protein HSPA4
(2010-11-17)The aims of this study were to determine the underlying causes of male infertility, growth retardation and cardiac hypertrophy in Hspa4-/- mice. In order to identify the spermatogenic ... -
Genetic and autoimmune modulators of brain function in neuropsychiatric illness and health
(2018-06-15)In the present thesis, the synergetic interaction between the nervous and immune systems and the potential pathological outcomes mediated by autoimmune processes targeting the brain was addressed, with a particular focus ... -
Identification of therapeutic targets in the Burkitt’s lymphoma specific B cell antigen receptor signaling network
(2018-11-12)Burkitt’s lymphoma (BL) is an aggressive B cell neoplasm that is characterized by a chromosomal translocation, which brings the proto-oncogene c-MYC under the control of Immunoglobulin (Ig) enhancer elements leading to ... -
Modeling anti-NMDAR encephalitis
(2022-07-22)The anti-NMDAR encephalitis (NMDARE) is an autoimmune condition with so far unclear etiology and pathogenesis. It manifests with a heterogeneous clinical disease course and is diagnosed based on the presence of ... -
Molecular mechanism of B cell antigen receptor-induced SHIP activation
(2012-03-05)Regulation of B cell activation is highly important to keep the balance between immunity and self-tolerance. The SH2 domain-containing 5 inositol phosphatase (SHIP) is an inhibitor of B ... -
Multimolecular adaptor protein complexes in B cell receptor signaling
(2015-07-03)The activation of B cells is the crucial step of the humoral immune response. This process is controlled by the B cell receptor (BCR) signaling pathway which is initiated by antigen recognition. An elaborated and detailed ... -
Nanobodies as new tools for studying large cargo transport and lamina organization
(2018-06-26)Nanobodies are the smallest recombinantly expressed antibody fragments, which show outstanding performance in numerous applications. In this work, we set out to generate nanobodies as tools to study nucleo-cytoplasmic ... -
NFATc1 driven ER-stress responses in the progression of non-alcoholic fatty liver disease
(2021-06-30)Non-alcoholic fatty liver disease (NAFLD) mirrors the hepatic manifestation of the metabolic syndrome and is defined by progressive fat accumulation in hepatocytes (steatosis). Uncomplicated NAFLD may progress to a severe ... -
Nucleoporin-binding nanobodies that either track or trap uclear pore complex assembly
(2021-03-25)Nuclear pore complexes (NPCs) are large multi-protein assemblies that control the transport of macromolecules between the nucleus and the cytoplasm. Their formation from ~ 1,000 individual polypeptides is an impressive ... -
Plasma Factors as Endogenous Agonists and Modulators of TLR4 Signaling in Microglia
(2010-06-30)Toll-like receptors (TLRs) comprise a family of pattern recognition receptors (PRRs) which recognize pathogen-associated molecular patterns (PAMPs) an assortment of evolutionary conserved ... -
Role of antibodies in autoimmunity of the central nervous system
(2020-07-09)Although T cells are the main players in multiple sclerosis (MS) and its animal model experimental autoimmune encephalomyelitis (EAE), the role of B cells and their soluble effector molecules (antibodies) is being progressively ...