Browse by type "cumulativeThesis"
Now showing items 1-20 of 92
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The Verticillium effector TRADE induces host plant cell identity switches by co-opting the osmotic stress and wound response pathways
(2024-10-08)Climate change not only increases the abiotic stress of our crops but also favors the spread of their pathogens. Thus, understanding the molecular mechanisms of plant-pathogen interactions is more important than ever. ... -
Development of Methods for Cardiac Tissue Characterization Using Magnetic Resonance Imaging in Animal Models
(2024-09-26)Cardiovascular diseases (CVDs) are the primary cause of death and disability globally. The progression of CVDs is often associated with functional and structural alterations, including reduced myocardial contractility, ... -
Characterization of Ca2+-triggered (de)ubiquitination events in depolarized synaptosomes by mass spectrometry
(2024-08-15)Communication between neurons takes place at synapses, where the transmission of information from the presynaptic neuron to the postsynaptic cell involves the Ca2+-regulated fusion of synaptic vesicles (SVs) with the ... -
Learning-dependent plasticity of the Drosophila mushroom body: An optophysiological approach
(2024-07-29)Functional changes in the neuronal network of our brain enable experience-dependent adaptations to the environment through our behavior, referred to as learning and memory. One fundamental topic has occupied the neurosciences ... -
Improving Cognition in Older Adults Through Transcranial Electrical Stimulation And Cognitive Training
(2024-07-23)The progressive aging of the global population continues unabated. Consequently, there is a substantial increase in the prevalence of neurocognitive disorders, primarily observed in the elderly. Current pharmacological ... -
Nanoscale organization of CaV1.3 L-type Ca2+ channel clusters in electrically excitable cells
(2024-06-18)A key player of excitable cells in the heart and brain is the L-type calcium channel CaV1.3, which translates electrical signals into a cellular response. In the heart, CaV1.3 holds a central role in pacemaking, signal ... -
Machine Learning-based Approaches to Integrate Heterogeneous Data for Biological Knowledge Transfer
(2024-06-13)Recent developments in high-throughput data generation methodologies, such as next-generation sequencing or MALDI-TOF mass spectrometry, are creating a strong necessity for data science to transform the field of biomedical ... -
Structural and functional connectivity in patients with major depressive disorder undergoing accelerated intermittent theta burst stimulation
(2024-06-05)Major depressive disorder (MDD) is one of the most prevalent mental health conditions, primarily characterized by depressed mood and loss of interest or pleasure. Cognitive impairments, including psychomotor agitation ... -
A Quantitative Mass Spectrometric Analysis of Signalling Proteins in Human Sperm Cells
(2024-05-17)Fertilization of an oocyte by a sperm cell is a complex multi-stage process. First, a sperm cell must locate and reach the oocyte; second, it must undergo capacitation, the acrosome reaction, and hyperactivation to penetrate ... -
Structural and biochemical studies on chromatin-protein complexes in transcription initiation
(2024-04-02)Gene expression is an essential process in the cell for the development and homeostasis of any organism. The eukaryotic genome is tightly packed with nucleosomes, the basic unit of chromatin, which protects DNA integrity. ... -
Amino acid metabolism in Bacillus subtilis
(2024-03-05)Amino acid metabolism is a a central field of research aiming to understand the complex reactions that take place in a cell. Amino acids are the main building blocks for proteins, and they serve as carbon or nitrogen source ... -
Molecular characterization of protein translocation pores
(2024-02-27)Within the intricate realm of intracellular protein transport, individual organelles are reliant upon precise and dedicated protein machineries, commonly referred to as translocon, to facilitate the translocation of proteins ... -
Identification and characterization of plant lipid droplet-associated proteins
(2024-02-23)The molecular study of plant lipid droplets, first described over a century ago, has garnered attention since the identification of oleosins in the 1980s’. In recent years, considerable progress has been achieved in ... -
Bayesian Structural Ensemble Determination from Single-Molecule X-ray Scattering
(2024-02-09)Single-molecule X-ray scattering experiments using ultrashort X-ray free electron laser (XFEL) pulses have opened a new route for the structure determination of biomolecules. They also hold the potential to extract the ... -
Phenotypic and Functional Characterization of Natural Killer Cell Receptors in Human and Rhesus macaque
(2024-02-05)Activating killer immunoglobulin-like receptors (KIRs) cannot transmit signals directly but through signaling motifs. Since human activating KIRs lack signaling molecules, their transmembrane lysine residue pairs with ... -
Quantitative molecular physiology at active zones of calyceal synapses of the auditory pathway
(2023-11-17)Bushy cells (BCs) of the anteroventral cochlear nucleus (aVCN) are the first relay station of ascending auditory information. Sound is transformed from mechanical to electrical stimuli by the inner hair cells of the cochlea ... -
Structural and functional investigation of tRNA guanine transglycosylase
(2023-11-17)In this thesis, two novel structures were presented, jointly illuminating dimerization and tRNA binding by human TGT. A first structure, obtained by X-ray crystallography, allowed to give a thorough account of the atomic ... -
Gene expression divergence during Drosophila head development on single nuclei resolution
(2023-11-01)In this work, I optimized single-nuclei and single-cell RNA sequencing protocols for working with small amounts of input tissue. Using one of these protocols, I generated 14 single-nuclei RNA expression datasets. These ... -
Illuminating the Morphological and Functional Plasticity of the Cochlear Inner Hair Cell Ribbon Synapse
(2023-10-24)Sound detection occurs in the cochlea, where sensory inner hair cells (IHC) accurately convert auditory stimuli into a neurochemical signal. Presynaptically, cochlear IHCs harbor highly-specialized electron-dense specializations ... -
Quantitative Nanoscopy of Synaptic Sites
(2023-08-23)Synapses are the basic information processing unit of the brain. Neuronal activity and memory formation thereby require a vastly dynamic and rapidly changing synaptic environment and composition. In order to function, these ...