Browse by type "cumulativeThesis"
Now showing items 1-20 of 99
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The role of Hsp42 in proteostasis-metabolism interplay and cellular longevity
(2025-01-23)Aging is a natural phenomenon characterized by a progressive decline despite complex pathways of maintenance and repair. Over time, cells experience profound changes in cell morphology as well as alterations in gene ... -
What an Insect Brain Can Tell Us: The Impact of Intrinsic and Extrinsic Factors on Long-Term Memory in Drosophila melanogaster Larvae
(2025-01-10)Learned associations can be consolidated into long-lasting memory traces, influenced by the relevance and abundance of information, as well as internal states of the animal. In adult Drosophila two distinct forms of ... -
Strategies for decreasing aneuploidy in mammalian oocytes
(2025-01-10)Female mammals experience a decline in fertility with age that has been attributed to the progressive depletion of the finite ovarian reserve and an increase in the incidence of aneuploid oocytes. Aneuploid oocytes can ... -
Molecular mechanisms and cellular functions of RNA methyltransferases targeting non-coding RNAs
(2024-12-23)Cellular RNAs contain diverse modified nucleotides that regulate their structure, stability, biogenesis and molecular functions. In abundant non-coding RNAs such as ribosomal (r)RNAs, transfer (t)RNAs and small nuclear ... -
Mechanisms of Ribosomal Translation studied by Molecular Dynamics Simulations
(2024-12-17)During translation, the ribosome moves along the mRNA and decodes the genetic information to synthesize proteins. This process proceeds in a step-wise iterative manner during which the ribosome undergoes conformational ... -
Host cell entry and antibody evasion of SARS-CoV-2 and animal sarbecoviruses
(2024-11-29)The emergence of SARS-CoV-2 has heightened global awareness of coronaviruses, following previous outbreaks of SARS-CoV and MERS-CoV, which originated in animals and were transmitted to humans, causing severe disease. ... -
Functions and Origins of Nonlinear Processing in the Retina
(2024-11-29)Millions of people worldwide suffer from terminal blindness, but state-of-the-art vision restoration devices can only produce a sensation fundamentally different from natural seeing. We lack the sufficient understanding ... -
The Verticillium effector TRADE induces host plant cell identity switches by co-opting the osmotic stress and wound response pathways
(2024-10-08)Climate change not only increases the abiotic stress of our crops but also favors the spread of their pathogens. Thus, understanding the molecular mechanisms of plant-pathogen interactions is more important than ever. ... -
Development of Methods for Cardiac Tissue Characterization Using Magnetic Resonance Imaging in Animal Models
(2024-09-26)Cardiovascular diseases (CVDs) are the primary cause of death and disability globally. The progression of CVDs is often associated with functional and structural alterations, including reduced myocardial contractility, ... -
Characterization of Ca2+-triggered (de)ubiquitination events in depolarized synaptosomes by mass spectrometry
(2024-08-15)Communication between neurons takes place at synapses, where the transmission of information from the presynaptic neuron to the postsynaptic cell involves the Ca2+-regulated fusion of synaptic vesicles (SVs) with the ... -
Learning-dependent plasticity of the Drosophila mushroom body: An optophysiological approach
(2024-07-29)Functional changes in the neuronal network of our brain enable experience-dependent adaptations to the environment through our behavior, referred to as learning and memory. One fundamental topic has occupied the neurosciences ... -
Improving Cognition in Older Adults Through Transcranial Electrical Stimulation And Cognitive Training
(2024-07-23)The progressive aging of the global population continues unabated. Consequently, there is a substantial increase in the prevalence of neurocognitive disorders, primarily observed in the elderly. Current pharmacological ... -
Nanoscale organization of CaV1.3 L-type Ca2+ channel clusters in electrically excitable cells
(2024-06-18)A key player of excitable cells in the heart and brain is the L-type calcium channel CaV1.3, which translates electrical signals into a cellular response. In the heart, CaV1.3 holds a central role in pacemaking, signal ... -
Machine Learning-based Approaches to Integrate Heterogeneous Data for Biological Knowledge Transfer
(2024-06-13)Recent developments in high-throughput data generation methodologies, such as next-generation sequencing or MALDI-TOF mass spectrometry, are creating a strong necessity for data science to transform the field of biomedical ... -
Structural and functional connectivity in patients with major depressive disorder undergoing accelerated intermittent theta burst stimulation
(2024-06-05)Major depressive disorder (MDD) is one of the most prevalent mental health conditions, primarily characterized by depressed mood and loss of interest or pleasure. Cognitive impairments, including psychomotor agitation ... -
A Quantitative Mass Spectrometric Analysis of Signalling Proteins in Human Sperm Cells
(2024-05-17)Fertilization of an oocyte by a sperm cell is a complex multi-stage process. First, a sperm cell must locate and reach the oocyte; second, it must undergo capacitation, the acrosome reaction, and hyperactivation to penetrate ... -
Structural and biochemical studies on chromatin-protein complexes in transcription initiation
(2024-04-02)Gene expression is an essential process in the cell for the development and homeostasis of any organism. The eukaryotic genome is tightly packed with nucleosomes, the basic unit of chromatin, which protects DNA integrity. ... -
Amino acid metabolism in Bacillus subtilis
(2024-03-05)Amino acid metabolism is a a central field of research aiming to understand the complex reactions that take place in a cell. Amino acids are the main building blocks for proteins, and they serve as carbon or nitrogen source ... -
Molecular characterization of protein translocation pores
(2024-02-27)Within the intricate realm of intracellular protein transport, individual organelles are reliant upon precise and dedicated protein machineries, commonly referred to as translocon, to facilitate the translocation of proteins ... -
Identification and characterization of plant lipid droplet-associated proteins
(2024-02-23)The molecular study of plant lipid droplets, first described over a century ago, has garnered attention since the identification of oleosins in the 1980s’. In recent years, considerable progress has been achieved in ...