Browse by type "cumulativeThesis"
Now showing items 1-20 of 106
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Transcriptomic Mechanisms in Post-mitotic and Excitable Cells in Inter-Organ Communication
(2025-12-04)The human body functions as an integrated network where organs communicate through complex molecular signals rather than as isolated systems. This inter-organ communication occurs through various mediators including proteins, ... -
Chromatin remodeling BAF complex dependent mechanisms in development of cortical interneurons
(2025-10-21)GABAergic inhibitory neurons contribute to the excitatory and inhibitory balance in the brain. Dysfunction in GABAergic neuron development is implicated in various neurodevelopmental disorders. In recent years, the ... -
Pharmacotherapeutic approaches against Plasmodium falciparum
(2025-06-23)Malaria tropica persists as one of the most impactful infectious diseases, threatening the health of nearly half of the world’s population every year. The disease is caused by Plasmodium falciparum (P. falciparum), a ... -
Protein Mobility in the Complex Physical Environment of the Synapse
(2025-05-22)Robust signal transmission between cells is vital for our daily lives. It relies on fine orchestration of many processes, particularly taking place at chemical synapses. Here, chemical reactions occur in precise order, ... -
Targeting SARS-CoV-2 with Nanobodies and Antibodies: Neutralization and Escape Variants
(2025-05-15)The SARS-CoV-2 pandemic revealed significant limitations in existing preventive measures against coronavirus infections. Before vaccines were approved, over 64 million infections and 1.6 million deaths were reported ... -
Sarcomere signaling in a patient-specific iPSC model of hypertrophic cardiomyopathy
(2025-03-07)Hypertrophic cardiomyopathy (HCM) is a severe cardiac disorder associated with ventricular hypertrophy, diastolic dysfunction, and arrhythmias, which can lead to heart failure. Inherited forms of HCM are frequently caused ... -
Constant pH Molecular Dynamics through λ-dynamics
(2025-02-26)This thesis presents a novel implementation of constant pH molecular dynamics simulations using λ-dynamics with Hamiltonian interpolation, enabled by an efficient Fast Multipole Method electrostatic solver. The accuracy ... -
The role of Hsp42 in proteostasis-metabolism interplay and cellular longevity
(2025-01-23)Aging is a natural phenomenon characterized by a progressive decline despite complex pathways of maintenance and repair. Over time, cells experience profound changes in cell morphology as well as alterations in gene ... -
What an Insect Brain Can Tell Us: The Impact of Intrinsic and Extrinsic Factors on Long-Term Memory in Drosophila melanogaster Larvae
(2025-01-10)Learned associations can be consolidated into long-lasting memory traces, influenced by the relevance and abundance of information, as well as internal states of the animal. In adult Drosophila two distinct forms of ... -
Strategies for decreasing aneuploidy in mammalian oocytes
(2025-01-10)Female mammals experience a decline in fertility with age that has been attributed to the progressive depletion of the finite ovarian reserve and an increase in the incidence of aneuploid oocytes. Aneuploid oocytes can ... -
Molecular mechanisms and cellular functions of RNA methyltransferases targeting non-coding RNAs
(2024-12-23)Cellular RNAs contain diverse modified nucleotides that regulate their structure, stability, biogenesis and molecular functions. In abundant non-coding RNAs such as ribosomal (r)RNAs, transfer (t)RNAs and small nuclear ... -
Mechanisms of Ribosomal Translation studied by Molecular Dynamics Simulations
(2024-12-17)During translation, the ribosome moves along the mRNA and decodes the genetic information to synthesize proteins. This process proceeds in a step-wise iterative manner during which the ribosome undergoes conformational ... -
Host cell entry and antibody evasion of SARS-CoV-2 and animal sarbecoviruses
(2024-11-29)The emergence of SARS-CoV-2 has heightened global awareness of coronaviruses, following previous outbreaks of SARS-CoV and MERS-CoV, which originated in animals and were transmitted to humans, causing severe disease. ... -
Functions and Origins of Nonlinear Processing in the Retina
(2024-11-29)Millions of people worldwide suffer from terminal blindness, but state-of-the-art vision restoration devices can only produce a sensation fundamentally different from natural seeing. We lack the sufficient understanding ... -
The Verticillium effector TRADE induces host plant cell identity switches by co-opting the osmotic stress and wound response pathways
(2024-10-08)Climate change not only increases the abiotic stress of our crops but also favors the spread of their pathogens. Thus, understanding the molecular mechanisms of plant-pathogen interactions is more important than ever. ... -
Development of Methods for Cardiac Tissue Characterization Using Magnetic Resonance Imaging in Animal Models
(2024-09-26)Cardiovascular diseases (CVDs) are the primary cause of death and disability globally. The progression of CVDs is often associated with functional and structural alterations, including reduced myocardial contractility, ... -
Characterization of Ca2+-triggered (de)ubiquitination events in depolarized synaptosomes by mass spectrometry
(2024-08-15)Communication between neurons takes place at synapses, where the transmission of information from the presynaptic neuron to the postsynaptic cell involves the Ca2+-regulated fusion of synaptic vesicles (SVs) with the ... -
Learning-dependent plasticity of the Drosophila mushroom body: An optophysiological approach
(2024-07-29)Functional changes in the neuronal network of our brain enable experience-dependent adaptations to the environment through our behavior, referred to as learning and memory. One fundamental topic has occupied the neurosciences ... -
Improving Cognition in Older Adults Through Transcranial Electrical Stimulation And Cognitive Training
(2024-07-23)The progressive aging of the global population continues unabated. Consequently, there is a substantial increase in the prevalence of neurocognitive disorders, primarily observed in the elderly. Current pharmacological ... -
Nanoscale organization of CaV1.3 L-type Ca2+ channel clusters in electrically excitable cells
(2024-06-18)A key player of excitable cells in the heart and brain is the L-type calcium channel CaV1.3, which translates electrical signals into a cellular response. In the heart, CaV1.3 holds a central role in pacemaking, signal ...