Browse by type "doctoralThesis"
Now showing items 1-20 of 1153
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The role of Sec61β in Ebola and Marburg virus glycoprotein processing and the potential of the Sec61 channel as antiviral target
(2025-11-10)Ebola virus (EBOV) and Marburg virus (MARV), members of the family of Filoviridae, are highly pathogenic for humans and non-human primates (NHPs) and lead to reoccurring outbreaks mainly in the region of West, East and ... -
The role of STAT1 signal transduction in the pathogenesis of Alzheimer’s disease
(2025-11-06)Chronic neuroinflammation is considered a key hallmark of Alzheimer’s disease (AD) and may represent a central mechanism in its pathogenesis. Microglia, the resident immune cells of the central nervous system (CNS), are ... -
In situ Structural Studies of α-Synuclein Fibrils
(2025-11-06)Protein aggregation into amyloid fibrils is a hallmark of many human diseases, yet the structural principles that govern fibril organization and their physiological consequences remain incompletely understood. This thesis ... -
Characterizing a Novel Powerful Channelrhodopsin Variant for Preclinical Studies on Optogenetic Cochlear Implants
(2025-10-29)Contemporary electrical cochlear implants (eCI) directly stimulate spiral ganglion neurons (SGNs) using electric current to partially restore auditory function in patients diagnosed with profound sensorineural hearing loss ... -
Investigating Mitochondrial Presequence Import
(2025-10-29)Mitochondrial biogenesis and function depend on the accurate import of nuclear-encoded proteins via specialized translocase complexes. Disruptions in these import pathways are implicated in numerous mitochondrial disorders, ... -
Advanced Correlation Spectroscopy and Nanofluidics in Single-Molecule Biophysics
(2025-10-28)Fluorescence Correlation Spectroscopy (FCS) is a powerful and widelyused technique in biophysics for studying biomolecules and their interactionsat the single-molecule level. However, traditional FCS hasnotable limitations. ... -
Immortalized Primate Granulosa Cell Lines and Pluripotent Stem Cell-Derived Early Germ Cells: Towards Ovarian Follicles In Vitro
(2025-10-24)Access to primate ovarian tissue and mature oocytes is extremely limited, yet these resources are crucial for advancing both infertility treatment and fundamental research in reproductive biology. Conventional sources are ... -
Role of PSD-95 in mouse binocular vision: A combined behavioural and 2-photon Ca2+ imaging study
(2025-10-22)Visual cortical circuits undergo a temporally restricted period of heightened plasticity early in neurodevelopment, termed the critical period (CP; Hubel and Wiesel, 1962, 1963). Crucial visual abilities, such as binocularity, ... -
Unexpected Evolutionary Invariance: Understanding a Major Transition in the Evolution of Networks of Orientation Selective Neurons
(2025-10-15)The mechanisms of development and function of neural architectures involved in information detection and processing of sensory stimuli is still largely unknown, despite these processes being crucial in mediating interactions ... -
Functional Characterization of Early Visual Neurons Using Machine Learning
(2025-10-02)Understanding how early visual neurons represent and process sensory input remains a central challenge in systems neuroscience. Key questions include how these neurons encode visual information, how their receptive fields ... -
Synaptic mechanisms of sound intensity coding in the cochlea
(2025-10-02)In the mammalian cochlea sensory inner hair cells (IHCs) convert the mechanical sound waves into receptor potential and transmit the signal to the spiral ganglion neurons (SGNs) via afferent synapses. SGNs receiving input ... -
Characterization of tumor suppressor SMAD4 as a novel regulator of genome instability in human cancer
(2025-09-24)Chromosomal instability (CIN) is characterized by an increased rate of generation of chromosomal alterations and is a hallmark of human cancer. CIN is strongly associated with genomic heterogeneity, therapeutic resistance, ... -
The roles of GTPases in biogenesis of the large ribosomal subunit
(2025-09-22)Ribosomes are ribonucleoprotein complexes responsible for protein synthesis, and their biogenesis is a complex, highly orchestrated process requiring a significant amount of energy and the coordinated action of all three ... -
The role of two families of lipid droplet-associated proteins
(2025-09-16)Lipid droplets (LDs) are unique subcellular compartments that are specialized for lipid storage. In recent years, the number of identified and characterized LD-associated proteins has been greatly increased, which, on the ... -
Transgenic fungal expression and characterization of a fluorescently-tagged variant of the Verticillium effector protein TRADEVd, and functional elucidation of its Fusarium homolog TRADEFo, and of another Verticillium effector candidate, LSCE1Vd
(2025-09-11)Vascular wilt fungi have an arsenal of secreted effector proteins, which manipulate the host physiology and immune system for their successful colonization. Among these effectors, Verticillium TRADEVd was previously ... -
Decoding Courtship Dynamics: The Role of Behavioral Rules, Feedback Cues and Internal State in Drosophila Interactions
(2025-08-29)The behavior of an organism is the result of sensorimotor transformations (behavioral rules) by which the brain integrates external sensory stimuli with its internal state to control a motor output and elicit a particular ... -
Development and Application of Camelid Single-Domain Antibodies for Live and Multiplexed Imaging of Synaptic Structure and Function
(2025-08-29)Optical microscopy has become one of the most powerful tools in biology, allowing the visualization of cells, subcellular structures, and molecular interactions, leading to a number of groundbreaking discoveries. Since the ... -
Effects of perturbed sumoylation and neddylation on synaptic transmission
(2025-08-22)Post-translational modifications (PTMs) regulate a wide range of cellular processes. PTMs involving ubiquitin-like modifiers (UBLs) have been implicated in neurodevelopment and brain diseases. Recent evidence indicates ... -
Understanding Visual Attention: A Multifaceted Approach
(2025-08-21)We all have an intuitive sense of what attention is, yet defining it precisely remains challenging. While research in psychology and neuroscience has explored its origins, mechanisms, and influence on behaviour for over a ... -
Mitochondrial Alterations in Rett Syndrome
(2025-08-19)Rett syndrome is a neurodevelopmental disorder and one of the primary causes of cognitive impairment in females. Affected individuals typically exhibit normal development until 6-18 months of age, followed by stagnation ...