GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften
Recent Submissions
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Flexibility and optimization of neural codes in primate sensory cortex
(2025-06-18)Flexibility and efficiency are core characteristics of any intelligent system. We have a remarkable capacity to continually learn from the structure in the world, predict upcoming situations and flexibly respond in a ... -
Deciphering novel pathomechanisms initiating and maintaining atrial fibrillation
(2025-06-17)Atrial fibrillation (AF) is the most common arrhythmia and AF burden is projected to rise in the next years. This may be partially attributed to limited efficacy of current antiarrhythmic therapies and interventions. A ... -
SNARE Cis-Reassembly: Investigating SNARE Interactions Post-Disassembly
(2025-06-16)Neurotransmitter release relies on the SNARE-mediated fusion of neurotransmitter-filled synaptic vesicles with the presynaptic plasma membrane. SNARE proteins from these opposing membranes interact to form a stable ... -
Inferring spreading dynamics of diseases and in neural networks
(2025-06-11)The rapid advancement in information technology over the past few decades has provided ample computational power and access to diverse data sources. In conjunction with recent inference methods, we can now examine the ... -
Structural and Mechanistic Interrogation of Fatty Acid Biosynthesis Machinery
(2025-05-22)Lipids are important molecules for vital functions in the cell, such as energy storage, membrane structure, cellular signaling, and metabolic control. Lipid metabolism is thus one of the central pathways of all living ... -
Protein Mobility in the Complex Physical Environment of the Synapse
(2025-05-22)Robust signal transmission between cells is vital for our daily lives. It relies on fine orchestration of many processes, particularly taking place at chemical synapses. Here, chemical reactions occur in precise order, ... -
Investigations of Signal-Enhanced Magnetic Resonance Contrast Agents
(2025-05-22)The subject of this thesis is to extend the scope of magnetic resonance imaging (MRI) to the visualization and characterization of metabolic activities. The inherent insensitivity of conventional MRI limits its applicability ... -
Computational Methods for Canonical and Noncanonical Peptide Identification in Immunopeptidomics
(2025-05-19)The presentation of peptides via the MHC-I pathway as signals to CD8+ T cells is an essential element of the adaptive immune system. Hence, effective identification of the peptides presented (i.e., the MHC-I immunopeptidome) ... -
Targeting SARS-CoV-2 with Nanobodies and Antibodies: Neutralization and Escape Variants
(2025-05-15)The SARS-CoV-2 pandemic revealed significant limitations in existing preventive measures against coronavirus infections. Before vaccines were approved, over 64 million infections and 1.6 million deaths were reported ... -
Investigating the Evolutionary History of Catarrhine Primates using Whole Genome Data
(2025-05-08)The aim of my PhD project is to investigate the evolutionary history and adaptive potential of diverse catarrhine primates using whole genome sequencing data, with a focus on Bale monkey (Chlorocebus djamdjamensis) and ... -
Characterization of TMEM209, a transmembrane protein of the nuclear envelope
(2025-04-29)The nuclear envelope (NE) comprises the outer nuclear membrane (ONM) and inner nuclear membrane (INM), which are connected at the level of nuclear pore complexes (NPCs). A variety of transmembrane proteins is found at the ... -
Characterization and Engineering of the 'Biocatalytic' Transketolase from Geobacillus stearothermophilus
(2025-04-24)Biocatalysis is the use of living organisms or their components to speed up chemical reactions, and is a powerful tool to enhance efficiency and sustainability in manufacturing processes. Carboligation, the formation of ... -
Molecular Physiology of Synaptic Sound Encoding
(2025-04-10)Cochlear inner hair cells (IHCs) of the auditory system form specialised chemical synapses called ribbon synapses with type I spiral ganglion neurons (SGNs). These synapses encode sound information into neural signals for ... -
Optimal Control Methods for Biomolecular NMR Spectroscopy
(2025-04-04)Bio-molecular NMR studies are usually limited by the sensitivity and resolution, especially for concentration limited samples such as IDPs, in-cell samples and metabolomics studies, etc. Hence it is essential to use a ... -
Cortical PV and VIP neurons are necessary for texture discrimination performance of freely behaving mice
(2025-03-27)Rodents gather information about their surroundings through their whiskers, enabling them to differentiate textures, recognize objects, and navigate. Each whisker is represented in the barrel cortex (S1BF) by a single ... -
Biochemical Characterization of Otoferlin, the Ca2+ sensor for exocytosis at inner hair cell synapses
(2025-03-27)Transmission of sound from the ear to the brain requires high temporal and spatial fidelity. Inner hair cells (IHC) of the inner ear are the primary sensory organ of hearing, forming the first synapse of the auditory ... -
Structural and biochemical studies on co-transcriptional endonuclease reactions
(2025-03-25)Influenza, an acute respiratory disease, causes 290,000 to 650,000 human deaths annually (Iuliano et al., 2018; WHO, 2023). During an influenza infection, the virus ensures proper handling of viral mRNA, including nuclear ... -
Viscoelastic properties of epithelial cells: 3D structures and composite elements
(2025-03-14)Epithelial cells form complex, polarized layers in the body to cover organs and cavities. While the mechanical properties of single cells and 2D monolayers have been extensively studied, recent research suggests that 3D ... -
Reconstitution and molecular characterisation of the mitochondrial membrane contact site
(2025-03-14)Due to their endosymbiotic origin, mitochondria of eukaryotic cells are enveloped by two membranes. While the outer membrane is rather flat, the inner membrane is intricately folded into subcompartments called cristae. ... -
Bone Morphogenetic Protein signaling in the planarian flatworm Schmidtea mediterranea – evolutionary, cellular, and spatial patterns
(2025-03-13)In early development, morphogen gradients orchestrate the establishment of body axes. Perturbations of such a fundamental process are often damaging to embryonal development, making it difficult to study the role of body ...