GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften
Recent Submissions
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Systemic ectomycorrhizal defense induction in poplar
(2023-05-25)Ectomycorrhizal fungi (EMF) are important soil symbiotes in boreal and temperate forests. They form beneficial interactions (ectomycorrhizae) with the roots of tree species. Ectomycorrhizae facilitate plant nutrient ... -
Pair-correlation effects in many-body systems
(2023-05-25)The laws of nature encompass the small, the large, the few, and the many. In this thesis we are concerned with classical (i.e. not quantum) many-body systems, which refers to any microscopic or macroscopic system that ... -
Nuclear transport of the nitric oxide synthase interacting protein (NOSIP)
(2023-05-23)Proteins that need to actively enter the nucleus are thought to be transported by a specific nuclear transport receptor (NTR), depending on the type of the nuclear localization signal (NLS). Some cargoes are reported to ... -
Biophysical and molecular mechanisms of mean and variance adaptation in the Drosophila ear
(2023-05-16)Adaptation is an important mechanism found across sensory systems and species. This important ability of sensory systems expands our range of perception. Giving us the ability to perceive a quiet whisper as well as a loud ... -
Neural circuit plasticity underlying learning and memory in Drosophila melanogaster: from synaptic connections to behavior
(2023-05-12)Understanding the principles behind olfactory higher-order associative chains formation in Drosophila is one step further into unraveling the essence of learning and memory. However, the rationale behind such mechanisms ... -
Crosstalk between the lung microenvironment and CNS autoimmunity
(2023-05-08)The contribution of the lung in shaping CNS autoimmunity is gaining relevance in the last years. Central nervous system (CNS) reactive T cells can acquire in the lung the potential to invade the CNS in experimental ... -
Structural interrogation of enzyme mechanism and dynamics
(2023-05-05)The pyruvate dehydrogenase complex (PDHc) is one of the largest macromolecular enzyme complexes, and serves an universally important metabolic function by converting pyruvate into acetyl-CoA. Therefore, the PDHc connects ... -
Complex Dynamics in the Spread of COVID-19
(2023-05-05)The COVID-19 pandemic is the most recent example that infectious diseases can disrupt and permanently alter how societies work and interact. This manuscript builds around a series of papers studying disease spread from the ... -
Biochemical reconstitution of human autophagy initiation
(2023-05-04)Autophagy is a tightly regulated process that eukaryotic cells use as a major survival mechanism to reallocate nutrients to essential processes in adverse conditions such as nutrient or energy deprivation. Autophagy is ... -
Molecular Dynamics Studies of Permeation and Gating Mechanisms in Potassium Channels
(2023-04-19)Potassium (K+) channels contribute to diverse physiological activities, representing an indispensable part of living organisms. A thorough understanding of different aspects of permeation mechanisms and gating in K+ channels ... -
Machine learning classification of patients with major depressive disorder and healthy controls using magnetic resonance imaging data
(2023-04-19)Major depressive disorder (MDD) is a prevalent and complex psychiatric disorder affecting more than 300 million people worldwide. It is characterized by a highly heterogeneous spectrum of symptoms, including low mood and ... -
Gene Expression Analysis in Models of Cognitive Diseases
(2023-04-18)Neuropsychiatric disorders and neurodegenerative diseases have been a subject of significant interest in the scientific community for several reasons. A considerable portion of the population experiences discomfort due to ... -
Characterizing intracellular lipid signaling in dilated cardiomyopathy using human iPSC-derived cardiac cells
(2023-04-18)Sarcomere protein misalignment is a primary consequence of inherited mutations causing dilated cardiomyopathy (DCM) and results in severe molecular patho-phenotypes in cardiomyocytes from patients. In this study, human ... -
Modulation of sensory processing under different modes of reward cueing
(2023-04-13)Rewards not only shape our value-based choices but also affect our simple perceptual decisions. Accordingly, behavioral and neural correlates of reward-driven effects on perception have already been identified at the ... -
The Verticillium dahliae Vta3 genetic network and hydrophobins are required in tomato xylem sap for plant disease
(2023-03-27)The ascomycete Verticillium dahliae is a pathogenic fungus for a variety of important crops and spends long phases of its life cycle in the vascular xylem system of particular host plants. Growth in this unique and ... -
Context, circuit and modulation of courtship signal selection in Drosophila
(2023-03-23)Communication is multi-modal -- when we interact, we speak, gesticulate, and touch. However, the neural computations and circuits that select and coordinate these communication signals are unclear. We address this issue ... -
Structure and function of bacterial viruses and viral communities
(2023-03-16)Bacterial viruses, known as bacteriophages or phages, are the most abundant biological entities on the planet and the least studied in terms of abundance and diversity. Searching the sequence databases of viral genomes, ... -
Functional Decomposition of Retinal Ganglion Cell Receptive Fields
(2023-02-23)The retina has the fascinating ability to extract various visual features from our surroundings. This feature detection is enabled by nonlinear operations in the retinal circuitry. The nonlinear processing is in part ... -
The Verticillium effector XFORCE1 targets a core component of plant mRNA turnover and induces cell identity switches
(2023-02-17)Previous research into Verticillium spp. infection on the model plant Arabidopsis thaliana revealed the existence of three distinct disease classes. Each of these could be characterised by the induction of contrasting ... -
Role of predisposing genetics, telomere signaling and crosstalk of cardiac fibroblasts and cardiomyocytes in a pluripotent stem cell model of dilated cardiomyopathy
(2023-02-16)Despite rapid scientific and medical advances, cardiovascular diseases represent a major threat to human health worldwide. Among these, cardiomyopathies are one of the leading causes of heart failure. Dilated cardiomyopathy ...