GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften
Recent Submissions
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Bayesian Inference for Top-Down Protein Markov Models and the Ubiquity of Michaelis-Menten Kinetics
(2024-10-04)The current understanding of protein function predominantly relies on the concept of describing proteins as comprising discrete conformational and chemical states including transitions between these states. The theory of ... -
Interactions between cytoskeletal filaments in cells
(2024-10-04)Essential functions of eukaryotic cells such as cell division, force generation and the ability to mechanically adapt to the outer environment depend on the cytoskeleton, which is an intricate network containing three ... -
Development of Analysis- and Simulation-Routines for ENDOR Spectroscopy
(2024-10-04)Electron paramagnetic resonance (EPR) spectroscopy allows obtaining structural information on for example biomolecules by investigating the magnetic environment of paramagnetic centers on the atomic to nanoscale. This ... -
Development of an in-silico framework for the engineering and evaluation of future optogenetic cochlear implants
(2024-09-27)Hearing loss is a prevalent global challenge with profound cognitive, psychological, social, and economic implications. Traditional cochlear implants (CIs)—neuroprosthetic devices to partially restore hearing—stimulate the ... -
Identification of novel rate-limiting components in Arabidopsis cell entry control against non-adapted fungal pathogens
(2024-09-27)Cell entry into host cells represents a crucial step during pathogenesis of fungal phytopathogens. However, plants have evolved an effective cell entry control mechanism to block a majority of intruders at the front line. ... -
Role of internal mRNA modifications in modulating translation elongation
(2024-09-26)Translation is a highly regulated process that defines the composition of the cellular proteome. Numerous mechanisms are known to fine-tune the translational output at different cellular conditions. Recently, a new regulatory ... -
Development of Methods for Cardiac Tissue Characterization Using Magnetic Resonance Imaging in Animal Models
(2024-09-26)Cardiovascular diseases (CVDs) are the primary cause of death and disability globally. The progression of CVDs is often associated with functional and structural alterations, including reduced myocardial contractility, ... -
Development of mass spectrometry-based proteome analysis workflows for the systematic study of cardiac disease research models
(2024-09-26)A specific variant of genetic mutation in the phospholamban gene expresses a cardiac phospholamban protein lacking the arginine amino acid at position 14 (R14Δ-PLN). The mutation is believed to have a founder in the ... -
Investigation of the Mitochondria-ER axis and its interconnection with the MICOS complex
(2024-09-19)Mitochondria-ER contact sites (MERCS) are essential cellular hubs for the exchange of signaling molecules, lipids and metabolites. A multitude of MERCS-associated proteins have been described in mammalian cells, and rising ... -
Characterization of Novel Proteins Modulating the Nanoscale Organization of the Membrane-Associated Periodic Skeleton in Neurons
(2024-09-19)The Membrane-associated Periodic Skeleton (MPS) is a lattice located underneath the neuronal plasma membrane, characterized by a distinctive ~190 nm periodic architecture imposed by the nanoscale arrangement of its main ... -
Nucleation of Chemically Active Droplets
(2024-09-10)The interior of a cell is a complicated mixture of many components, and dynamics need to be orchestrated in time and space to ensure the proper functioning of the cell. One key strategy for achieving this tight control is ... -
Investigation of the fusion machinery reconstituted into novel pore-spanning membranes
(2024-09-06)The release of neurotransmitter into the synaptic cleft is achieved by fusion of synaptic vesicles with the presynaptic membrane. This essential process in the neuronal signal transmission is driven by the soluble ... -
Characterization of stress-induced cytosolic assemblies containing components of the guided-entry of tail-anchored proteins targeting pathway
(2024-09-04)Up to 30% of eukaryotic proteins are integral membrane proteins and need to be targeted to their appropriate membrane locations. The guided entry of tail-anchored proteins (GET) is a key targeting route to the ER membrane ... -
Pairing transcranial direct current stimulation and mindfulness meditation in the treatment of fibromyalgia
(2024-08-22)The lack of effective treatments for managing pain and associated symptoms in fibromyalgia (FM) poses both a clinical challenge and an economic burden on the health sector. Typical FM therapies include an array of ... -
Tracing evolutionary patterns across the green lineage with respect to protein families and pathways in response to stress
(2024-08-22)The evolutionary history of Chloroplastida is unique, as it includes the emergence of those organisms that make up the macroscopic flora on land: the land plants (embryophytes). The land plants arose from a singular ... -
Mechanistic Characterization of CDK9 Inhibition in T-Cell Lymphoma
(2024-08-20)Mature T-cell lymphomas (mTCL) comprise a rare group of lymphoid malignancies with very diverse genetical, clinical, and pathological characteristics that are in many cases associated with poor prognosis. Current therapy ... -
Resolving chromatin interaction and transcriptional networks in mammalian nuclei
(2024-08-15)The nucleus is a highly organized machine. Chromatin organization, transcription, and RNA processing are working harmoniously in a specialized but communicative way to pass the information from DNA to mature RNA. In the ... -
Characterization of Ca2+-triggered (de)ubiquitination events in depolarized synaptosomes by mass spectrometry
(2024-08-15)Communication between neurons takes place at synapses, where the transmission of information from the presynaptic neuron to the postsynaptic cell involves the Ca2+-regulated fusion of synaptic vesicles (SVs) with the ... -
Investigations of signal-enhanced magnetic resonance contrast agents
(2024-08-15)Nuclear magnetic resonance spectroscopy (NMR spectroscopy) and its related technique, magnetic resonance imaging (MRI), enable scientists and doctors to make statements about the atomic structure of a sample and to ... -
Computational methods for prokaryotic (meta)genomic annotation and function prediction using horizontal information transfer
(2024-08-05)In recent decades, there has been a surge in genomic sequences resulting from large-scale genomic and metagenomic sequencing projects, driven by the significant drop in sequencing costs. More powerful methods to annotate ...