GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften
Recent Submissions
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Analysis of multifunctional RNA helicase regulation by protein cofactors in different gene expression processes
(2023-09-11)The biogenesis of ribonucleoprotein (RNP) complexes is a fundamental process in the gene expression network. Assembly of eukaryotic ribosomes and spliceosomes is highly orchestrated and entails the formation of numerous ... -
A pilot study assessing neurophysiological and cardiovascular effects of non-invasive vagus nerve stimulation in healthy subjects and patients with restless legs syndrome
(2023-08-31)Background: Transcutaneous auricular vagus nerve stimulation (taVNS) is an auspicious neurostimulation technique intensively investigated for its potential antidepressant, anticonvulsive, anti-inflammatory and analgesic ... -
Quantitative Nanoscopy of Synaptic Sites
(2023-08-23)Synapses are the basic information processing unit of the brain. Neuronal activity and memory formation thereby require a vastly dynamic and rapidly changing synaptic environment and composition. In order to function, these ... -
Lipids in plant development and stress responses
(2023-08-22)In plant cells, lipids are important components of cellular membranes. There, they act as structure-forming and/or signal-transmitting elements. As signals, lipids are landmarks and thereby important regulators, for example ... -
The role of pulvinar during perceptual decision-making and thalamic interactions with cardiac and respiratory activity in macaques
(2023-08-22)The dorsal pulvinar (dPul), a higher-order thalamic hub, is instrumental in spatial orienting and selecting stimuli in our environment by gating cortico-thalamic-cortical communication. However, its precise role in perceptual ... -
Quantitative Multi-Parameter Mapping in Magnetic Resonance Imaging
(2023-08-18)Magnetic resonance imaging (MRI) is a versatile imaging technology with a broad variety of biomedical and clinical applications. It provides an excellent soft tissue contrast without the need for ionizing radiation or ... -
Hydrodynamics of Ciliary Systems
(2023-08-15)The interactions of cilia with one another and their environment are central to many important questions in biology. These hairlike organelles are found in motile and immotile (or `primary') variants, and have a variety ... -
Self-Organization in Catalytically Active Mixtures
(2023-08-14)Living systems are intrinsically out of equilibrium, which makes their physical description challenging. This has led to the emergence, over the past thirty years, of a new field of physics, active matter, which studies ... -
Functional characterisation of DHX proteins in the regulation of RNA metabolism and genome stability
(2023-08-08)Cells contain a multitude of different RNAs, which are highly versatile biomolecules that have crucial functions in almost all cellular processes. Furthermore, the inter-relationship between RNA and proteins is essential, ... -
The evolution of hydrophobic barriers among land plants
(2023-08-03)The terrestrialization of plants required major physiological and metabolic adaptations, including the capacity to deposit extracellular hydrophobic barriers that shield plant surfaces against various abiotic and biotic ... -
Pathophysiological effects of Beta-Synuclein mutants P123H and V70M
(2023-07-24)Mutations in the beta-synuclein protein have been directly linked to Dementia with Lewy bodies (DLB). In particular, P123H mutation was linked to a familial case of DLB, whereas V70M mutation was identified in a sporadic ... -
Elongation factor P: mechanism of action and opportunities for drug design
(2023-07-24)EF-P is a conserved protein that has shape similarity to the tRNAs and binds to the E site of the ribosome. EF-P enhances the rate of peptide bond formation during the synthesis of polyPro sequences. In E. coli one third ... -
RNA Interactions of the Zebrafish Germ Plasm Organizer Bucky ball
(2023-07-24)Reproduction is the fundamental feature of all living organisms, ensuring their survival and continuance. For their reproduction, multicellular organisms develop highly specialized cells, termed germ cells. In many animals, ... -
A Multidisciplinary Approach to Neuropathic Pain: Assessing Tactile Sensation and Neuroma Pain Factors
(2023-07-18)Neuropathic pain is a complex and often debilitating condition. Distally from the injury site, missing input contributes to deafferentation pain, while proximally, neuroma formation leads to peripheral and central ... -
Reorganization of the Senescent Genome via Spatial CTCF Clustering
(2023-07-13)Cellular senescence is now understood to be a major hallmark of the aging process. Senescence can be induced by many stress factors, including telomere shortening, DNA damage and tumor- suppressor genes activation and ... -
Dependency of 3D chromatin folding on RNA polymerase II at different cell cycle stages
(2023-07-13)In human cells, the genetic information is organised in a multilayer fashion. During the cell cycle, chromatin undergoes dramatic structural changes. For proper inheritance, chromatin is compacted to chromosomes in ... -
Development of 13C Liquid State Dynamic Nuclear Polarization at 9.4 Tesla
(2023-07-11)Throughout the last decades, nuclear magnetic resonance (NMR) spectroscopy in liquids contributed to the structural elucidation of molecules of many types and sizes. Continuous improvements of the hardware and pulse sequences ... -
Ultrastructural study of synaptic vesicle dynamics in murine inner hair cell ribbon synapses under sustained stimulation
(2023-07-11)Transmission of auditory information relies in the correct functioning of inner hair cell (IHC) rib-bon synapses, which mediate synaptic vesicle release in an indefatigable manner. The name-giving synaptic ribbon and the ... -
Optimal navigation in active matter
(2023-07-11)Motile active matter systems are composed of a collection of agents, each of which extracts energy from the surrounding environment in order to convert it into self-driven motion. At the microscopic scale, however, directed ... -
Functional characterization of Arabidopsis thaliana CC-type glutaredoxin ROXY9
(2023-07-10)Glutaredoxins are small proteins with a conserved thioredoxin fold. This fold allows for two functions, depending on the sequence of the active site. Class I glutaredoxins, which are characterized by a CPYC motif, show ...