GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften
Recent Submissions
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Molecular Mechanisms of Neuro Transmittewr Release at Dorsal Root Ganglion Neurons
(2026-01-22)Dorsal root ganglion (DRG) neurons are essential for transmitting peripheral sensory information to the central nervous system and play a central role in nociception and pain-related pathophysiology. Despite their clinical ... -
Evolution of insect neural cell types revealed by single cell sequencing
(2026-01-21)The insect central nervous system, composed of the ventral nerve cord and brain, develops from neural stem cells (neuroblasts), which are largely conserved among insects. According to Drosophila studies, the brain develops ... -
Theory of Chromosomal Crossover Placement
(2026-01-21)Chromosomes encode genetic information in living organisms. In species that reproduce sexually, each cell contains a maternal and a paternal copy of each homologous chromosome. During meiosis, a special type of cell division ... -
Deciphering the molecular mechanisms determining spore type-specific development and pathogenicity in Colletotrichum graminicola
(2026-01-21)Colletotrichum graminicola is a hemibiotrophic fungal pathogen that causes anthracnose disease in Zea mays (maize). This pathogen produces two distinct types of asexual spores: falcate and oval conidia, each specialized ... -
Sending AI to Med School: Increasing the Level of Evidence in Evaluation and Development of AI-ECG Models for Cardiovascular Diseases
(2026-01-21)Artificial intelligence (AI) models trained on electrocardiograms (AI-ECG) can automatically learn highly specific disease pattern for cardiovascular risk assessment and diagnosis. However, it is typically not clear which ... -
Dissecting STRIPAK-mediated signaling pathways in the ascomycete Sordaria macrospora using proximity-dependent Biotin Identification
(2026-01-16)The filamentous ascomycete Sordaria macrospora (Sm) serves as a model to study fruiting body development with the aim of uncovering the fundamental processes that shape the differentiation of multicellular eukaryotic life. ... -
Analysis of unconventional plant defence suppression by the signal peptide peptidase Spp1 in the Ustilago maydis - maize interaction
(2026-01-15)In the smut fungus Ustilago maydis, the signal peptide peptidase (SPP) Spp1 is essential for plant defence suppression and establishment of a compatible biotrophic interaction with its host plant maize. SPPs are endoplasmic ... -
Dissection of the initial steps and dynamics in synaptic vesicle biogenesis using custom-refined nano-affinity tools
(2026-01-14)Synaptic vesicles (SVs) are among the most complex cellular structures studied in neuroscience. They consist of several different components that must be precisely assembled to perform numerous important functions, not ... -
The effect of parasitic plants on host plant immunity against microbial pathogens
(2026-01-13)Plants in natural environments are frequently exposed to multiple biotic and abiotic stresses, and their combined effects often trigger complex and non-additive physiological and molecular responses (Suzuki et al., 2014). ... -
Intraspecific signalling regulates protohaustorium formation in the parasitic plant Phtheirospermum japonicum
(2026-01-12)Mass occurrences of parasitic plants from the Orobanchaceae family pose significant challenges in agricultural settings. The impact of parasitic weeds such as Striga and Rhamphicarpa increases markedly with parasite density, ... -
Mechanisms of mitochondrial RNA maturation
(2026-01-06)Cellular energy production is essential for sustaining life and is largely enabled by the presence of a functional respiratory chain in mitochondria. The proper assembly and function of this system are crucial for cellular ... -
Dynamic Gain Analysis of Neuronal Response in Experimental and Computational Models under Electrical and Optogenetic Stimulation
(2025-12-17)Local cortical circuits in the mammalian neocortex encode and process information through the coordinated spiking activity of large neuronal populations. Despite the high variability and low firing rate of individual spike ... -
Bioinformatic analyses of complex genomic regions in non-human primate genomes
(2025-12-10)This PhD thesis investigates the application of bioinformatics techniques to annotate and explore complex genomic regions, with an emphasis on the immune-related Natural Killer Group 2 (NKG2) genes in non-human primates. ... -
Transcriptomic Mechanisms in Post-mitotic and Excitable Cells in Inter-Organ Communication
(2025-12-04)The human body functions as an integrated network where organs communicate through complex molecular signals rather than as isolated systems. This inter-organ communication occurs through various mediators including proteins, ... -
The Role of Synaptic Signalling Activity in Brain Development
(2025-12-02)Dynamic changes in synapse structure are essential for memory formation and require newly synthesized synaptic proteins to either replace aged or damaged proteins, or to alter synaptic signalling efficacy (Costa-Mattioli ... -
Investigations of New Magnetic Resonance Contrast Agents
(2025-11-26)Magnetic resonance spectroscopy (MRS) and imaging (MRI) are powerful noninvasive techniques for probing biochemical composition and anatomy. However, the inherently low sensitivity of these magnetic resonance techniques ... -
Fidelity of protein synthesis in vivo
(2025-11-12)Protein synthesis fidelity is essential for maintaining proteome integrity and cellular fitness. Errors, such as amino acid misincorporations caused by incorrect decoding, result in aberrant proteins that promote proteotoxic ... -
The role of Sec61β in Ebola and Marburg virus glycoprotein processing and the potential of the Sec61 channel as antiviral target
(2025-11-10)Ebola virus (EBOV) and Marburg virus (MARV), members of the family of Filoviridae, are highly pathogenic for humans and non-human primates (NHPs) and lead to reoccurring outbreaks mainly in the region of West, East and ... -
In situ Structural Studies of α-Synuclein Fibrils
(2025-11-06)Protein aggregation into amyloid fibrils is a hallmark of many human diseases, yet the structural principles that govern fibril organization and their physiological consequences remain incompletely understood. This thesis ... -
The role of STAT1 signal transduction in the pathogenesis of Alzheimer’s disease
(2025-11-06)Chronic neuroinflammation is considered a key hallmark of Alzheimer’s disease (AD) and may represent a central mechanism in its pathogenesis. Microglia, the resident immune cells of the central nervous system (CNS), are ...