GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften
Recent Submissions
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Streptophyte evolution: plastidial signals and core abiotic stress physiology of the closest algal relatives to embryophytes
(2023-12-04)Plant terrestrialization facilitated the emergence of the enormous and diverse macroflora. It changed the face of our planet. On this singular evolutionary event, which occurred approximately 550 million years ago, land ... -
The role of pulvinar-parietal circuitryin goal-directed saccades
(2023-11-28)The pulvinar, an important higher-order thalamic nucleus supporting many functions, is reciprocally connected with frontoparietal areas involved in sensorimotor transformations. Priorperturbation studies also revealed its ... -
Synthesis of molecular probes for the hyperpolarization with parahydrogen
(2023-11-28)Nuclear magnetic resonance spectroscopy (NMR) and related nuclear magnetic resonance imaging (MRI) allow us to acquire information about molecules at an atomic level and thereby create images of human tissues and organs ... -
Structural and functional investigation of tRNA guanine transglycosylase
(2023-11-17)In this thesis, two novel structures were presented, jointly illuminating dimerization and tRNA binding by human TGT. A first structure, obtained by X-ray crystallography, allowed to give a thorough account of the atomic ... -
Quantitative molecular physiology at active zones of calyceal synapses of the auditory pathway
(2023-11-17)Bushy cells (BCs) of the anteroventral cochlear nucleus (aVCN) are the first relay station of ascending auditory information. Sound is transformed from mechanical to electrical stimuli by the inner hair cells of the cochlea ... -
Force information integration in the primate fronto-parietal reach network
(2023-11-10)The primate sensorimotor system relies on force predictions, when executing a motor command with a certain force. Yet it remains unclear if the sensorimotor system uses these force predictions to prepare a motor command ... -
Regulation of plant stress responses by clade I TGA transcription factors and interacting CC-type glutaredoxins
(2023-11-09)TGACG-BINDING (TGA) transcription factors are important regulators in numerous processes such as pathogen defense, development and detoxification. To control some of these responses, plant specific CC type glutaredoxins ... -
Giant plasma membrane vesicle-derived in vitro systems to study the structure and dynamics of CaV1.3 channel clusters
(2023-11-06)The voltage-gated calcium channel 1.3 (CaV1.3) has plentiful tasks in the human body. One of them is the excitation-contraction coupling within the heart, where it is known to form CaV1.3 channel cluster. However, their ... -
A theory of inference and learning in cortex with spiking neurons and dendritic error computation
(2023-11-03)How the cortex performs its intricate computations, and how it adapts to the world around it, is one of the central mysteries in neuroscience. It is a longstanding belief that one of the main aims of the brain, and especially ... -
Proteomic Profiles of Campylobacter jejuni and Enterococci during Co-incubation and under Bile Acid Stress
(2023-11-03)The human gut harbors a complex ecosystem of microbial communities, consisting of commensal inhabitants, which play crucial roles in maintaining gut homeostasis, regulating host metabolism, and modulating immune responses. ... -
Gene expression divergence during Drosophila head development on single nuclei resolution
(2023-11-01)In this work, I optimized single-nuclei and single-cell RNA sequencing protocols for working with small amounts of input tissue. Using one of these protocols, I generated 14 single-nuclei RNA expression datasets. These ... -
Illuminating the Morphological and Functional Plasticity of the Cochlear Inner Hair Cell Ribbon Synapse
(2023-10-24)Sound detection occurs in the cochlea, where sensory inner hair cells (IHC) accurately convert auditory stimuli into a neurochemical signal. Presynaptically, cochlear IHCs harbor highly-specialized electron-dense specializations ... -
Mechanism of non-canonical ubiquitination by ubiquitin conjugating enzyme Ubc6
(2023-10-18)Protein quality control by ubiquitination occurs due to the sequential action of three enzyme classes: ubiquitin-activating (E1), ubiquitin-conjugating (E2) and ubiquitin-ligases (E3). Conventionally, ubiquitin (Ub) ... -
Interplay between α-synuclein expression and 26S proteasome chaperone Rpn14 and Rpn11 deubiquitinase in the budding yeast Saccharomyces cerevisiae
(2023-10-17)Alpha-synuclein (αSyn) in a misfolded state is the main component of Lewy bodies (LBs). These filamentous cytoplasmic inclusions are the neuropathological hallmark of Parkinson’s disease (PD). αSyn aggregates in LBs are ... -
Analysis of multifunctional RNA helicase regulation by protein cofactors in different gene expression processes
(2023-09-11)The biogenesis of ribonucleoprotein (RNP) complexes is a fundamental process in the gene expression network. Assembly of eukaryotic ribosomes and spliceosomes is highly orchestrated and entails the formation of numerous ... -
A pilot study assessing neurophysiological and cardiovascular effects of non-invasive vagus nerve stimulation in healthy subjects and patients with restless legs syndrome
(2023-08-31)Background: Transcutaneous auricular vagus nerve stimulation (taVNS) is an auspicious neurostimulation technique intensively investigated for its potential antidepressant, anticonvulsive, anti-inflammatory and analgesic ... -
Quantitative Nanoscopy of Synaptic Sites
(2023-08-23)Synapses are the basic information processing unit of the brain. Neuronal activity and memory formation thereby require a vastly dynamic and rapidly changing synaptic environment and composition. In order to function, these ... -
Lipids in plant development and stress responses
(2023-08-22)In plant cells, lipids are important components of cellular membranes. There, they act as structure-forming and/or signal-transmitting elements. As signals, lipids are landmarks and thereby important regulators, for example ... -
The role of pulvinar during perceptual decision-making and thalamic interactions with cardiac and respiratory activity in macaques
(2023-08-22)The dorsal pulvinar (dPul), a higher-order thalamic hub, is instrumental in spatial orienting and selecting stimuli in our environment by gating cortico-thalamic-cortical communication. However, its precise role in perceptual ... -
Quantitative Multi-Parameter Mapping in Magnetic Resonance Imaging
(2023-08-18)Magnetic resonance imaging (MRI) is a versatile imaging technology with a broad variety of biomedical and clinical applications. It provides an excellent soft tissue contrast without the need for ionizing radiation or ...