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Assoziation der Campylobacter jejuni ssp. jejuni Chemotaxisrezeptorgene mit Multilokussequenztypen und Isolationsquellen

dc.contributor.advisorZautner, Andreas Prof. Dr.
dc.contributor.authorEmrich, Norah L.A.
dc.titleAssoziation der Campylobacter jejuni ssp. jejuni Chemotaxisrezeptorgene mit Multilokussequenztypen und Isolationsquellende
dc.title.translatedAssociation of Campylobacter jejuni ssp. jejuni chemotaxis receptor genes with multilocus sequence types and source of isolationde
dc.contributor.refereeZautner, Andreas Prof. Dr.
dc.description.abstractengCampylobacter jejuni’s flagellar locomotion is controlled by eleven chemoreceptors. Assessment of the distribution of the relevant chemoreceptor genes in the C. jejuni genomes deposited in the National Center for Biotechnology Information (NCBI) database led to the identification of two previously unknown tlp genes and a tlp5 pseudogene. These two chemoreceptor genes share the same locus in the C. jejuni genome with tlp4 and tlp11, but the gene region encoding the periplasmic ligand binding domain differs significantly from other chemoreceptor genes. Hence, they were named tlp12 and tlp13. Consequently, it was of interest to study their distribution in C. jejuni subpopulations of different clonality, and their cooccurrence with the eleven previously reported chemoreceptor genes. Therefore, the presence of all tlp genes was detected by polymerase chain reaction (PCR) in 292 multilocus sequence typing (MLST)-typed C. jejuni isolates from different hosts. The findings show interesting trends: Tlp4, tlp11, tlp12, and tlp13 appeared to be mutually exclusive and cooccur in a minor subset of isolates. Tlp4 was found to be present in only 33.56% of all tested isolates and was significantly less often detected in turkey isolates. Tlp11 was tested positive in only 17.8% of the isolates, while tlp12 was detected in 29.5% of all isolates, and tlp13 was found to be present in
dc.contributor.coRefereeUhmann, Anja PD Dr.
dc.subject.engCampylobacter jejunide
dc.affiliation.instituteMedizinische Fakultätde
dc.subject.gokfull:Medizinische Mikrobiologie / Medizinische Virologie / Medizinische Mykologie / Infektionskrankheiten / Hygiene / Impfung / Parasitologie / Tropenmedizin - Allgemein- und Gesamtdarstellungen (PPN619875356)de

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