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Network formation and reorganization of the olfactory system of Xenopus laevis

dc.contributor.advisorManzini, Ivan Prof. Dr.
dc.contributor.authorHawkins, Sara Joy
dc.titleNetwork formation and reorganization of the olfactory system of Xenopus laevisde
dc.contributor.refereeStaiger, Jochen Prof. Dr.
dc.description.abstractengThe olfactory system is a window to the chemical world, that permits each species to adapt to novel spaces and situations. Despite the various phylogenetic adaptations, this sensory system maintains similar functional and structural features (Eisthen, 2002). One of these shared features is the regenerative capability of the olfactory system, due to the maintenance of stem cell niches that replace neurons throughout life and after lesion. The disruption and damage of olfactory systems in different spe-cies allows us to compare these neurogenic processes and potentially find features that are more or less permissive for the recovery of function, potentially providing clin-ical relevance (Lledo and Valley, 2016; Shohayeb et al., 2018). I lesioned the olfactory system of larval Xenopus laevis, by severing the olfactory nerve, causing loss of olfactory function. Over the course of approximately 2 months, distinct populations of ORNs are regenerated, capable of accurately rewiring in the OB, leading to the morphological and functional recovery of second order neurons and consequently to the recovery of odor representations in the brain that allow for odor recognition (Hawkins et al., 2017; Hawkins et al., in prep). I show that odor-guided behavioral changes are lost after ON transection, and recover after a 7 to 9 week period after lesion (Hawkins et al., in prep). My finding show a clear interplay between peripheral and central nervous system trophic support during the process of recovery from damage. Further comparative analyses of recovery from olfactory sys-tem lesion between vertebrate phyla would contribute to the understanding of what factors or mechanisms promote or inhibit the recovery of odor
dc.contributor.coRefereeDean, Camin Dr.
dc.contributor.thirdRefereeHeinrich, Ralf Prof. Dr.
dc.contributor.thirdRefereeFiala, André Prof. Dr.
dc.contributor.thirdRefereeGöpfert, Martin Prof. Dr.
dc.subject.engaquatic olfactionde
dc.subject.engde- and regenerationde
dc.subject.engnerve transectionde
dc.subject.engodor coding/mappingde
dc.subject.engfunctional calcium imagingde
dc.affiliation.instituteGöttinger Graduiertenschule für Neurowissenschaften, Biophysik und molekulare Biowissenschaften (GGNB)de
dc.subject.gokfullBiologie (PPN619462639)de

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