Troponin-Test im Alltag

Al Mawed, Mohammad

Beeinflussung der Gütekriterien durch Leitsymptome und Unterschiede des Outcomes von Patienten mit auffälligem Test und Patienten mit unauffälligem Test

dc.contributor.advisor	Tebbe, Ulrich, Prof. Dr.
dc.contributor.author	Al Mawed, Mohammad
dc.date.accessioned	2022-04-01T13:30:41Z
dc.date.available	2022-04-26T00:50:10Z
dc.date.issued	2022-04-01
dc.identifier.uri	http://resolver.sub.uni-goettingen.de/purl?ediss-11858/13964
dc.identifier.uri	http://dx.doi.org/10.53846/goediss-9125
dc.language.iso	deu	de
dc.rights.uri	http://creativecommons.org/licenses/by/4.0/
dc.subject.ddc	610	de
dc.title	Troponin-Test im Alltag	de
dc.title.alternative	Beeinflussung der Gütekriterien durch Leitsymptome und Unterschiede des Outcomes von Patienten mit auffälligem Test und Patienten mit unauffälligem Test	de
dc.type	doctoralThesis	de
dc.title.translated	Troponin test in clinical daily practice	de
dc.contributor.referee	Tebbe, Ulrich, Prof. Dr.
dc.date.examination	2022-04-19	de
dc.description.abstracteng	Abstract Introduction Cardiac troponins are the prefered cardial biomarker in the diagnosis of acute myocardial infarction. With the new Troponin-Assays minimal troponin concentration can be detectable. This makes the interpretation of a positive test very difficult, taking to consideration the wide variety of causes of troponin release. The aim of this study is to assess the quality criteria of the troponin test in the diagnosis of acute myocardial infarction in everyday life and asses the influence of leading symptom on the quality criteria of the test. Methods This is a retrospective cross-sectional study, patients, who presented themselves in the emergency department of the Klinikum Lippe-Detmold between 01.01.2014 and 31.05.2014, and had a Troponin-I test, were included. The diagnosis “acute myocardial infarction” referred to myocardial infarction type I and was made by the cardiologist on-duty. The patients were divided into four subgroups according to their leading symptoms. The quality criteria of the Troponin-test were calculated. Results 1046 patients were included. In 15 %, acute myocardial infarction was present, of which 97 % had thoracic pain. The sensitivities and the negative predictive values were over 90 %. The specificities ranged between 56 % and 81 %. The positive predictive values were modest and best in case of thoracic pain 58 %. Conclusion The Troponin test had a good negative predictive value for all clinical symptoms. Thus, an acute myocardial infarction could be excluded with high precision. However, the positive predictive value was low. The only direct symptom that achieved acceptable levels was thoracic pain.	de
dc.contributor.coReferee	Schnelle, Moritz Thomas, PD Dr. Dr.
dc.title.alternativeTranslated	Influence of key symptoms on quality criteria and differences in the outcome of patients with abnormal tests and patients with normal tests	de
dc.subject.ger	kardiale Troponine - akuter Myokardinfarkt - Myokardverletzung - thorakale Schmerzen - Dyspnoe	de
dc.subject.eng	cardiac troponins - acute myocardial infarction - myocardial injury - thoracic pain - dyspnea	de
dc.identifier.urn	urn:nbn:de:gbv:7-ediss-13964-1
dc.affiliation.institute	Medizinische Fakultät	de
dc.subject.gokfull	:Kardiologie (PPN619875755)	de
dc.description.embargoed	2022-04-26	de
dc.identifier.ppn	1799351564

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Human- und Zahnmedizin [2872]

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