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Towards a total synthesis of bazzanin K

dc.contributor.advisorAlcarazo, Manuel Prof. Dr.
dc.contributor.authorRugen, Christian Johann
dc.date.accessioned2022-05-31T13:42:56Z
dc.date.issued2022-05-31
dc.identifier.urihttp://resolver.sub.uni-goettingen.de/purl?ediss-11858/14077
dc.identifier.urihttp://dx.doi.org/10.53846/goediss-9278
dc.language.isoengde
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subject.ddc540de
dc.titleTowards a total synthesis of bazzanin Kde
dc.typedoctoralThesisde
dc.contributor.refereeAlcarazo, Manuel Prof. Dr.
dc.date.examination2022-03-24de
dc.description.abstractengBazzanin K is a natural product from the group of macrocyclic bis-bibenzyls which was isolated from the liverwort bazzania trilobata. This work is dedicated towards the development of a synthetic strategy with bazzanin K at the end. Similar macrocyclic bis-bibenzyls have been prepared and their literature known syntheses shall serve as an inspiration. In a first step, unsubstituted model substances were prepared successfully to test the viability of pi-acid catalysis for the synthesis of a phenanthrene motif and an intramolecular Wittig reaction for a macrocyclization as key steps in the total synthesis. For the preparation of bazzanin K four aromatic building blocks were prepared with a variety of different substitution patterns. Different synthetic strategies for the connection of these units were tested and important key intermediates were obtained.de
dc.contributor.coRefereeKoszinowski, Konrad Prof. Dr.
dc.contributor.thirdRefereeAckermann, Lutz Prof. Dr.
dc.contributor.thirdRefereeJanßen-Müller, Daniel Dr.
dc.contributor.thirdRefereeSteinem, Claudia Prof. Dr.
dc.contributor.thirdRefereeJohn, Michael Dr.
dc.subject.engbazzanin Kde
dc.subject.engtotal synthesisde
dc.subject.engpi-acid catalysisde
dc.subject.engcross coupling reactionde
dc.subject.engaromatic compoundde
dc.subject.engmacrocyclizationde
dc.subject.engWittig reactionde
dc.subject.engmacrocyclic bis-bibenzylde
dc.identifier.urnurn:nbn:de:gbv:7-ediss-14077-4
dc.date.embargoed2023-03-23
dc.affiliation.instituteFakultät für Chemiede
dc.subject.gokfullChemie  (PPN62138352X)de
dc.description.embargoed2023-03-23de
dc.identifier.ppn1806821869


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