Towards a total synthesis of bazzanin K

Rugen, Christian Johann

dc.contributor.advisor	Alcarazo, Manuel Prof. Dr.
dc.contributor.author	Rugen, Christian Johann
dc.date.accessioned	2022-05-31T13:42:56Z
dc.date.available	2023-03-23T00:50:09Z
dc.date.issued	2022-05-31
dc.identifier.uri	http://resolver.sub.uni-goettingen.de/purl?ediss-11858/14077
dc.identifier.uri	http://dx.doi.org/10.53846/goediss-9278
dc.language.iso	eng	de
dc.rights.uri	http://creativecommons.org/licenses/by/4.0/
dc.subject.ddc	540	de
dc.title	Towards a total synthesis of bazzanin K	de
dc.type	doctoralThesis	de
dc.contributor.referee	Alcarazo, Manuel Prof. Dr.
dc.date.examination	2022-03-24	de
dc.description.abstracteng	Bazzanin K is a natural product from the group of macrocyclic bis-bibenzyls which was isolated from the liverwort bazzania trilobata. This work is dedicated towards the development of a synthetic strategy with bazzanin K at the end. Similar macrocyclic bis-bibenzyls have been prepared and their literature known syntheses shall serve as an inspiration. In a first step, unsubstituted model substances were prepared successfully to test the viability of pi-acid catalysis for the synthesis of a phenanthrene motif and an intramolecular Wittig reaction for a macrocyclization as key steps in the total synthesis. For the preparation of bazzanin K four aromatic building blocks were prepared with a variety of different substitution patterns. Different synthetic strategies for the connection of these units were tested and important key intermediates were obtained.	de
dc.contributor.coReferee	Koszinowski, Konrad Prof. Dr.
dc.contributor.thirdReferee	Ackermann, Lutz Prof. Dr.
dc.contributor.thirdReferee	Janßen-Müller, Daniel Dr.
dc.contributor.thirdReferee	Steinem, Claudia Prof. Dr.
dc.contributor.thirdReferee	John, Michael Dr.
dc.subject.eng	bazzanin K	de
dc.subject.eng	total synthesis	de
dc.subject.eng	pi-acid catalysis	de
dc.subject.eng	cross coupling reaction	de
dc.subject.eng	aromatic compound	de
dc.subject.eng	macrocyclization	de
dc.subject.eng	Wittig reaction	de
dc.subject.eng	macrocyclic bis-bibenzyl	de
dc.identifier.urn	urn:nbn:de:gbv:7-ediss-14077-4
dc.affiliation.institute	Fakultät für Chemie	de
dc.subject.gokfull	Chemie (PPN62138352X)	de
dc.description.embargoed	2023-03-23	de
dc.identifier.ppn	1806821869

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