Exercise-induced microRNA modulations and their role in cognition

Goldberg, Maria

dc.contributor.advisor	Fischer, André Prof. Dr.
dc.contributor.author	Goldberg, Maria
dc.date.accessioned	2022-09-27T07:24:10Z
dc.date.available	2022-10-11T00:50:12Z
dc.date.issued	2022-09-27
dc.identifier.uri	http://resolver.sub.uni-goettingen.de/purl?ediss-11858/14259
dc.identifier.uri	http://dx.doi.org/10.53846/goediss-9462
dc.language.iso	eng	de
dc.rights.uri	http://creativecommons.org/licenses/by/4.0/
dc.subject.ddc	610	de
dc.title	Exercise-induced microRNA modulations and their role in cognition	de
dc.type	doctoralThesis	de
dc.contributor.referee	Fischer, André Prof. Dr.
dc.date.examination	2022-10-04	de
dc.description.abstracteng	The number of people suffering from dementia is constantly increasing leading to massive long-term economic and social consequences. A healthy lifestyle and physical exercise in particular are well known for their positive effects on brain functions. Epigenetics has great potential to provide us with answers on how benefits from physical exercise can be applied to cognitively impaired elderly patients and reverse age-related and disease-associated loss of normal cognitive function. MicroRNA is a novel tool to manipulate a wide range of physiological processes as single microRNA regulates the functions of multiple genes. We found two microRNAs that were upregulated in human blood as well as in stimulated mouse muscle cells and mouse brain after physical exercise, and we validated their role in neuronal plasticity. Inhibition of microRNA-409-5p and microRNA-501-3p negatively alters neuronal morphology and electrophysiological activity in mouse wild type hippocampal neurons. Moreover, expression of microRNA-409-5p was found to be decreased in patients with genetic frontotemporal dementia. Transplantation of media from electrically stimulated muscle may alter neuronal morphology. Overexpression of microRNA-409-5p and microRNA-501-3p increases spine number but does not have an effect on mature synapse number or action potentials of wild type healthy hippocampal neurons. Further studies are needed to validate experimentally other microRNAs from the identified cluster.	de
dc.contributor.coReferee	Outeiro, Tiago Fleming Prof. Dr.
dc.subject.ger	MicroRNome	de
dc.subject.ger	Transcriptome	de
dc.subject.ger	MicroRNA modulation	de
dc.subject.ger	Neuropsychology	de
dc.subject.ger	Behavioural experiments	de
dc.subject.ger	Neuronal plasticity	de
dc.subject.eng	Epigenetics	de
dc.subject.eng	MicroRNA	de
dc.subject.eng	Neurodegeneration	de
dc.subject.eng	Molecular neuroscience	de
dc.subject.eng	Cognition	de
dc.subject.eng	Exercise	de
dc.identifier.urn	urn:nbn:de:gbv:7-ediss-14259-9
dc.affiliation.institute	Medizinische Fakultät	de
dc.subject.gokfull	Psychiatrie (PPN619876344)	de
dc.description.embargoed	2022-10-11	de
dc.identifier.ppn	1817741055
dc.identifier.orcid	0000-0002-0706-7529	de
dc.notes.confirmationsent	Confirmation sent 2022-09-27T07:45:01	de

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Human- und Zahnmedizin [2873]

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