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Probing SNARE-Induced Membrane Fusion Using Peptidic Model Fusogens

dc.contributor.advisorDiederichsen, Ulf Prof. Dr.
dc.contributor.authorSelvachandran, Pirajeev
dc.date.accessioned2022-11-10T09:35:11Z
dc.date.available2022-11-17T00:50:09Z
dc.date.issued2022-11-10
dc.identifier.urihttp://resolver.sub.uni-goettingen.de/purl?ediss-11858/14335
dc.identifier.urihttp://dx.doi.org/10.53846/goediss-9548
dc.language.isoengde
dc.subject.ddc540de
dc.titleProbing SNARE-Induced Membrane Fusion Using Peptidic Model Fusogensde
dc.typedoctoralThesisde
dc.contributor.refereeSteinem, Claudia Prof. Dr.
dc.date.examination2021-12-13de
dc.description.abstractengIn this thesis, SNARE analogues with artificial recognition units made of either coiled-coil sequences or peptide nucleic acid (PNA) oligomers were synthesized. By applying FRET-based liposome fusion assays, the fusogenic character of SNARE analogues were investigated. The extent of liposome fusion were controllable by the type of the recognition units. Therefore, structural changes of these specific recognition units were applied in order to obtain a detailed insight of the liposome fusion process.de
dc.contributor.coRefereeTittmann, Kai Prof. Dr.
dc.subject.engHigh-performance liquid chromatography (HPLC)de
dc.subject.engSolid-phase peptide synthesis (SPPS)de
dc.subject.engSNARE-mimeticsde
dc.subject.engLiposome fusion assaysde
dc.identifier.urnurn:nbn:de:gbv:7-ediss-14335-7
dc.affiliation.instituteFakultät für Chemiede
dc.subject.gokfullChemie  (PPN62138352X)de
dc.description.embargoed2022-11-17de
dc.identifier.ppn1822038979
dc.notes.confirmationsentConfirmation sent 2022-11-10T09:45:02de


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