Diagnostische Vergleichbarkeit der kardialen Troponine I und T

Fraune, Laura Elisa

dc.contributor.advisor	Eidizadeh, Abass Dr.
dc.contributor.author	Fraune, Laura Elisa
dc.date.accessioned	2022-11-14T09:42:28Z
dc.date.available	2022-11-21T00:50:08Z
dc.date.issued	2022-11-14
dc.identifier.uri	http://resolver.sub.uni-goettingen.de/purl?ediss-11858/14338
dc.identifier.uri	http://dx.doi.org/10.53846/goediss-9536
dc.language.iso	deu	de
dc.rights.uri	http://creativecommons.org/licenses/by/4.0/
dc.subject.ddc	610	de
dc.title	Diagnostische Vergleichbarkeit der kardialen Troponine I und T	de
dc.type	doctoralThesis	de
dc.contributor.referee	Asif, Abdul Rahman Prof. Dr.
dc.date.examination	2022-11-14	de
dc.description.abstracteng	Cardiac troponins are crucial for the diagnosis of acute myocardial infarction. Despite known differences in their diagnostic implication, there are no recommendations for only one of the two troponins, cardiac troponin I (cTnI) and troponin T (cTnT) so far. In an everyday routine diagnostic, cTnT (Roche) as well as cTnI (Abbott) were measured in 5667 samples from 3264 patient cases. We investigated the number of identical or discrepant troponin findings. Regarding cTnI, we considered both, sex-dependent and unisex cutoffs. In particular, the number of cTnT positive and cTnI negative results was strikingly high in 14.0% of cTnT positive samples and increases to 23.8% by using sex-specific cTnI cutoffs. This group was considerably greater than the group of cTnI positive and cTnT negative results, also after elimination of patients with an eGFR < 60 mL/min/1.73 m2. Comparing the troponin cases with a dynamic increase or decrease between two measurements, we saw a balanced number of discrepant cases (between cTnT+/cTnI- and cTnT-/cTnI+), which was, however, still present. Using ROC analysis, sex-dependent cutoffs improved sensitivity and specificity of cTnI. This study shows in a large cohort that comparing the two cardiac troponins does not amount to identical analytical results. Consideration of sex-dependent cutoffs may improve sensitivity and specificity.	de
dc.contributor.coReferee	Sandek, Anja PD Dr.
dc.subject.eng	99th percentile upper reference limit	de
dc.subject.eng	cardiac biomarker	de
dc.subject.eng	cutoffs	de
dc.subject.eng	myocardial infarction	de
dc.subject.eng	sex-specific	de
dc.subject.eng	troponin I	de
dc.subject.eng	troponin T	de
dc.identifier.urn	urn:nbn:de:gbv:7-ediss-14338-4
dc.affiliation.institute	Medizinische Fakultät	de
dc.subject.gokfull	Medizin (PPN619874732)	de
dc.subject.gokfull	Labormedizin / Klinische Chemie - Allgemein- und Gesamtdarstellungen (PPN61987564X)	de
dc.description.embargoed	2022-11-21	de
dc.identifier.ppn	1822373530
dc.notes.confirmationsent	Confirmation sent 2022-11-14T09:45:06	de

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Human- und Zahnmedizin [2870]

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