Nephrotoxizität bei immunsuppressiver Therapie nach Lebertransplantation Ein systematischer Review und Metaanalyse
by Narin Bari
Date of Examination:2022-11-29
Date of issue:2022-11-22
Advisor:Prof. Dr. Tim Friede
Referee:Prof. Dr. Jürgen Brockmöller
Referee:Prof. Dr. Ralf Dressel
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Name:Dissertation Narin Bari 141122.pdf
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EnglishIt is known that calcineurin inhibitors (CNI), tacrolimus and cyclosporine have acute and chronic nephrotoxic effects. Liver transplant recipients get CNI after transplantation. Therefore, are used to spare CNI other non-nephrotoxic drugs in addition to or instead of CNI to improve kidney function. This systematic review and meta-analysis of randomized controlled trials showed that, MMF can either be used de novo in the immediate post-transplant period in combination with low-dose CNI (Scenario 1), or patients receiving CNI-based immunosuppression can be switched MMF in combination with minimization or elimination of CNI (Scenario 2). Furthermore, the following endpoints have been analysed in this dissertation, acute rejection, death and transplant loss.
Keywords: Acute kidney injury; chronic renal failure; Liver transplant