Nephrotoxizität bei immunsuppressiver Therapie nach Lebertransplantation Ein systematischer Review und Metaanalyse

Bari, Narin

dc.contributor.advisor	Friede, Tim Prof. Dr.
dc.contributor.author	Bari, Narin
dc.date.accessioned	2022-11-22T16:17:39Z
dc.date.available	2022-12-07T00:50:08Z
dc.date.issued	2022-11-22
dc.identifier.uri	http://resolver.sub.uni-goettingen.de/purl?ediss-11858/14356
dc.identifier.uri	http://dx.doi.org/10.53846/goediss-9558
dc.format.extent	999	de
dc.language.iso	deu	de
dc.rights.uri	http://creativecommons.org/licenses/by/4.0/
dc.subject.ddc	610	de
dc.title	Nephrotoxizität bei immunsuppressiver Therapie nach Lebertransplantation Ein systematischer Review und Metaanalyse	de
dc.type	doctoralThesis	de
dc.contributor.referee	Brockmöller, Jürgen Prof. Dr.
dc.date.examination	2022-11-29	de
dc.description.abstracteng	It is known that calcineurin inhibitors (CNI), tacrolimus and cyclosporine have acute and chronic nephrotoxic effects. Liver transplant recipients get CNI after transplantation. Therefore, are used to spare CNI other non-nephrotoxic drugs in addition to or instead of CNI to improve kidney function. This systematic review and meta-analysis of randomized controlled trials showed that, MMF can either be used de novo in the immediate post-transplant period in combination with low-dose CNI (Scenario 1), or patients receiving CNI-based immunosuppression can be switched MMF in combination with minimization or elimination of CNI (Scenario 2). Furthermore, the following endpoints have been analysed in this dissertation, acute rejection, death and transplant loss.	de
dc.contributor.coReferee	Dressel, Ralf Prof. Dr.
dc.subject.eng	Acute kidney injury	de
dc.subject.eng	chronic renal failure	de
dc.subject.eng	Liver transplant	de
dc.identifier.urn	urn:nbn:de:gbv:7-ediss-14356-4
dc.affiliation.institute	Medizinische Fakultät	de
dc.subject.gokfull	Medizinische Statistik / Biometrie / Epidemiologie - Allgemein- und Gesamtdarstellungen (PPN619875046)	de
dc.description.embargoed	2022-12-07	de
dc.identifier.ppn	1823235298
dc.notes.confirmationsent	Confirmation sent 2022-11-23T06:15:01	de

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Human- und Zahnmedizin [2872]

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