Epidemiologischer Vergleich und Analyse der operativen Versorgung von Patienten mit Lippen-, Kiefer-, Gaumenspalten - eine Mono-Center Analyse

Epidemiological comparison and evaluation of the surgical care of patients with orofacial clefts: A mono-center analysis

by Johanna Luise Charlotte Kolle
Doctoral thesis
Date of Examination:2022-12-01
Date of issue:2022-11-29
Advisor:PD Dr. Philipp Kauffmann
Referee:PD Dr. Philipp Kauffmann
Referee:Prof. Dr. Arno Olthoff
Persistent Address: http://dx.doi.org/10.53846/goediss-9580

 

 

Files in this item

Name:Kolle_ Johanna Luise Charlotte_Dissertation ...pdf
Size:1.28Mb
Format:PDF

The following license files are associated with this item:

Abstract

English

From 2001 to 2019 404 patients with orofacial clefts have visited the clinic for maxillofacial surgery in Göttingen. An increasement of case numbers has shown during this period, even higher in male patients. The gender distribution between male and female patients was 1.34 : 1. CLP was most common (39.1%), followed by CP (34.7%), CL (14.4%), CLA (9.9%), and facial clefts (2%). The left side was more frequently affected and unilateral cleft forms occurred more often than bilateral ones. Except of the group of patients with CLA, every other cleft form has shown more male patients than female. 10.9% of all patients had a positive family history, predominantly from the maternal side and from family members of a first degree relationship. Pregnancy abnormalities were found in 11.4%, most often in form of preterm birth, followed by gestational diabetes and the use of nicotine during pregnancy. 9.9% of the population showed syndromic CL/P, most commonly in combination with the Pierre- Robin-Sequence. Comorbidities were found in 30.2% of the sample, in the group of non-syndromic cleft patients especially of the cardiovascular system. 981 operations have been performed in this collective, with an increasement of the operation numbers during the years. 61 of those procedures where corrective surgeries. In comparison to the international literature the epidemiological and clinical profile of the study population resembled the expected distributions in western populations. The large number of syndromic CL/P and associated comorbidities supports the need for specialized cleft centers and interdisciplinary cleft care.
Keywords: orofacial cleft; cleft lip and/or palate; Epidemiology; Nonsyndromic/ syndromic clefting; surgical care
 
Statistik