Dissektion der prognostischen Heterogenität komplexer Anomalien beim myelodysplastischen Syndrom (MDS) durch Entwicklung eines Punkte Scores

Arps, Nicolas

dc.contributor.advisor	Schanz, Julie Prof. Dr.
dc.contributor.author	Arps, Nicolas
dc.date.accessioned	2023-01-11T14:46:54Z
dc.date.available	2023-01-19T00:50:10Z
dc.date.issued	2023-01-11
dc.identifier.uri	http://resolver.sub.uni-goettingen.de/purl?ediss-11858/14446
dc.identifier.uri	http://dx.doi.org/10.53846/goediss-9652
dc.format.extent	Seiten	de
dc.language.iso	deu	de
dc.subject.ddc	610	de
dc.title	Dissektion der prognostischen Heterogenität komplexer Anomalien beim myelodysplastischen Syndrom (MDS) durch Entwicklung eines Punkte Scores	de
dc.type	doctoralThesis	de
dc.contributor.referee	Burfeind, Peter Prof. Dr.
dc.date.examination	2023-01-11	de
dc.description.abstracteng	The aim of this work was the development of an additive score for the prognostic classification of myelodysplastic syndrome (MDS) patients with three or more chromosomal abnormalities. To create the score, 253 patients were analyzed retrospectively. This score enables a prognostic classification using different parameters. Factors such as the influence of aberrations, cytopenias, the amount of blast cells and their combined occurrence have been taken into account. In this study a connection between anomaly combinations with statistically unexpected frequency and distinct anomalies as well as their prognostic value in relation to the survival time of MDS patients could be shown. Evidence could be provided that the combination of some anomalies not yet specifically associated with MDS has a negative effect on the course of the disease. The score developed in this work is used to classify MDS patients with a complex karyotype into three different risk groups depending on aberrations and other clinical parameters.	de
dc.contributor.coReferee	Sennhenn-Kirchner, Sabine PD Dr.
dc.subject.eng	myelodysplastic syndrome	de
dc.subject.eng	chromosomal abnormalities	de
dc.subject.eng	complex karyotype	de
dc.identifier.urn	urn:nbn:de:gbv:7-ediss-14446-4
dc.affiliation.institute	Medizinische Fakultät	de
dc.subject.gokfull	Medizin (PPN619874732)	de
dc.subject.gokfull	MED 424	de
dc.subject.gokfull	MED 417	de
dc.description.embargoed	2023-01-19	de
dc.identifier.ppn	1830880292
dc.notes.confirmationsent	Confirmation sent 2023-01-11T15:15:01	de

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