Transition Metal- and Electro-Catalyzed C-H and B-H Activation for the Efficient Synthesis of Carborane Derivatives

von Becky Bongsuiru Jei
Dissertation
Datum der mündl. Prüfung:2022-12-15
Erschienen:2023-01-12
Betreuer:Prof. Dr. Lutz Ackermann
Gutachter:Prof. Dr. Lutz Ackermann
Gutachter:Prof. Dr. Alexander Breder
Gutachter:Prof. Dr. Dr. h.c. Lutz Tietze
Gutachter:Prof. Dr. Dietmar Stalke
Gutachter:Dr. Daniel Janßen-Müller
Gutachter:Dr. Michael John
Zum Verlinken/Zitieren: http://dx.doi.org/10.53846/goediss-9654

 

 

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Name:Thesis 04.01.2023.pdf
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Description:PhD Dissertation

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The emergence and rapid development of transition metal-and electro-catalyzed C-H activation has proven to be a powerful tool in the assembly of complex molecular structures. in addition, the selective synthesis of carborane derivatives proceeded over the years through noble 4d metal catalysis characterized by expensive 4d metal complexes, use of stoichiometric silver salts as well as harsh reaction conditions. This has made these protocols impractical and unsustainable thereby creating a need for more sustainable protocols. The above mentioned drawbacks have been partly addressed in this dissertation through the merge of 3d transition metal catalysis and electrocatalysis for the sustainable synthesis of carborane derivatives. Notable futures of this dissertation include i) cost-efficient, earth-abundant manganese(I) catalysis for the assembly of o-carborane containing peptides ii) copper(I)-catalyzed electrooxidative cage chalcogenation of o-carboranes iii) metal-free electrochemical B-H nitrogenation of nido-carboranes for the successful synthesis of highly fluorescent BODIPY containing nido-carboranes. Furthermore, we have unraveled sustainable methods to assemble carboranes of varying functional groups and complexity. These compounds could find application in medicine as novel boron neutron capture therapy agents and in material science for optoelectronic materials.
Keywords: sustainable catalysis, C-H/B-H activation, Carborane derivatives
Schlagwörter: sustainable catalysis, C-H/B-H activation, Carborane derivatives
 
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